Detection of Brown Adipose Tissue by Magnetic Resonance Imaging
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/24/2018 |
| Start Date: | September 2014 |
| End Date: | October 2019 |
| Contact: | Kristine Baluyot |
| Email: | kristine_baluyot@med.unc.edu |
| Phone: | (919) 843-5420 |
Assessment of MRI Accuracy for the Detection of Brown Adipose Tissue Using FDG-PET as a Gold Standard
The primary goal of this study is to assess the accuracy of conventional fat fraction proton
MRI for the detection of Brown Adipose Tissue (BAT) in healthy subjects using FDG-PET as gold
standard.
In this pilot study, MRI and PET imaging of BAT of healthy adult volunteers will be performed
on a combined PET/MRI scanner under mild cold condition.
MRI for the detection of Brown Adipose Tissue (BAT) in healthy subjects using FDG-PET as gold
standard.
In this pilot study, MRI and PET imaging of BAT of healthy adult volunteers will be performed
on a combined PET/MRI scanner under mild cold condition.
In the fight against obesity, brown adipose tissue (BAT) is considered to be the newest
target. The hypothesis is that this tissue is partially responsible for the imbalance between
energy intake and energy expenditure that keeps lean people lean and obese people obese.
The detection of this tissue in adult humans represents an unmet need. BAT is difficult to
detect and measurements of tissue fat fraction performed by magnetic resonance imaging have
been proposed as a mean to differentiate the highly hydrated brown fat from the less hydrated
white adipose tissue and from muscle.
To this end, the objective of this study is to assess the accuracy of magnetic resonance fat
fraction measurements for the detection of BAT volume in adult humans, while using FDG-PET as
gold standard.
For this study subjects will undergo a combined MRI/PET scan. The scans will be done during
stimulation of thermogenic activity by mild cold exposure.
target. The hypothesis is that this tissue is partially responsible for the imbalance between
energy intake and energy expenditure that keeps lean people lean and obese people obese.
The detection of this tissue in adult humans represents an unmet need. BAT is difficult to
detect and measurements of tissue fat fraction performed by magnetic resonance imaging have
been proposed as a mean to differentiate the highly hydrated brown fat from the less hydrated
white adipose tissue and from muscle.
To this end, the objective of this study is to assess the accuracy of magnetic resonance fat
fraction measurements for the detection of BAT volume in adult humans, while using FDG-PET as
gold standard.
For this study subjects will undergo a combined MRI/PET scan. The scans will be done during
stimulation of thermogenic activity by mild cold exposure.
Inclusion Criteria:
- Each subject must be fully informed and have signed consent.
- BMI < 34
- Normal neurological and psychological development / able to give consent
- Willingness to participate in this study
Exclusion Criteria:
- Subjects less than 18 years of age
- Severe claustrophobia
- Women who are pregnant, nursing an infant or planning to become pregnant in the next
30 days
- People who have a condition that makes MRI unsafe for them (for example, cardiac
pacemaker, epicardial pacemaker leads, cochlear implants, metal aneurysm clip, iron
filings in your eyes or metal halo devices)
- Have had radiation therapy or chemotherapy in the 2 months prior to PET scan
- Subjects are taking medications that may interfere with BAT detection
We found this trial at
2
sites
Chapel Hill, North Carolina 27599
Principal Investigator: Rosa Tamara Branca, P
Phone: 919-843-5420
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