Study of Cardiac MRI in Patients With Left-Sided Breast Cancer Receiving Radiation Therapy
| Status: | Recruiting |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/13/2019 |
| Start Date: | September 2014 |
| End Date: | July 2020 |
| Contact: | Intake Coordinator |
| Phone: | 877-686-6009 |
Prospective Pilot Study of Early Markers of Radiation-Induced Cardiac Injury in Patients With Left-Sided Breast Cancer Receiving Photon or Proton Therapy
This is a pilot study to determine if there are changes in heart function following
completion of radiation therapy for breast cancer as measured by cardiac magnetic resonance
imaging (cardiac MRI) scans. Additional purposes of this study are to assess cardiac side
effects from radiation treatment, evaluate cardiac MRI changes by radiation technique, and
compare quality of life questionnaires.
completion of radiation therapy for breast cancer as measured by cardiac magnetic resonance
imaging (cardiac MRI) scans. Additional purposes of this study are to assess cardiac side
effects from radiation treatment, evaluate cardiac MRI changes by radiation technique, and
compare quality of life questionnaires.
As part of this study, participants will have a cardiac MRI at baseline and a follow-up
cardiac MRI within 1 year after completion of standard radiation therapy for left-sided
breast cancer. The cardiac MRI scans will be evaluated to determine if there are changes in
cardiac function within 1 year after radiation treatment.
Patients will be asked to complete a questionnaire before and after treatment that asks about
their health and any symptoms they may be having.
Physical exams and any other standard of care service or treatment will be at the discretion
of the treating physician.
cardiac MRI within 1 year after completion of standard radiation therapy for left-sided
breast cancer. The cardiac MRI scans will be evaluated to determine if there are changes in
cardiac function within 1 year after radiation treatment.
Patients will be asked to complete a questionnaire before and after treatment that asks about
their health and any symptoms they may be having.
Physical exams and any other standard of care service or treatment will be at the discretion
of the treating physician.
Inclusion Criteria:
- Left-sided breast cancer stage I-III.
- Indications for adjuvant regional nodal and breast or chest wall radiation therapy
(RT).
- Women and men are allowed.
- Must be at least 18 years old at time of consent.
Exclusion Criteria:
- Pregnant and/or breastfeeding women or patients of child-producing potential not
willing to use contraception while on study.
- Prior history of cardiovascular disease per physician discretion.
- Stage 0 and IV breast cancer.
- Prior radiation therapy to chest.
- Concurrent trastuzumab per physician discretion.
- Contraindications to cardiac MRI (e.g., contrast reaction, metal implants, etc.).
We found this trial at
1
site
2015 Jefferson St
Jacksonville, Florida 32206
Jacksonville, Florida 32206
(904) 588-1800
Principal Investigator: Julie A Bradley, MD
Phone: 877-686-6009
University of Florida Proton Therapy Institute When the University of Florida Proton Therapy Institute opened...
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