Physical Activity and Obesity
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Endocrine, Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 30 - 60 |
| Updated: | 4/2/2016 |
| Start Date: | February 2014 |
| End Date: | April 2017 |
| Contact: | Scott M Chadderdon, MD |
| Email: | chadderd@ohsu.edu |
| Phone: | 503-494-8750 |
Physical Activity and Obesity: The Role of Nitric Oxide and Eicosanoids in Regulating Capillary Perfusion and Vascular Insulin Resistance
The purpose of the study is to see if a twelve-week exercise intervention in overweight or
obese subjects with pre-diabetes or early disease course type 2 diabetes can lead to
improved skeletal muscle capillary blood flow by improving substances that dilate blood
vessels and result in improved insulin sensitivity.
obese subjects with pre-diabetes or early disease course type 2 diabetes can lead to
improved skeletal muscle capillary blood flow by improving substances that dilate blood
vessels and result in improved insulin sensitivity.
Inclusion Criteria:
1. Males and females ages 30-60 years of age
2. Overweight and Obese (28< BMI <45)
3. Confirmed pre-diabetic (5.7≤ HbA1c < 6.5)
4. Type 2 DM, Diagnosis 2 years or less, on no medications or metformin only, HbA1c ≤
6.7
Exclusion Criteria:
1. Stage 3 chronic kidney disease (glomerular filtration rate [GFR] < 60)
2. Obstructive Coronary artery disease
3. Congestive heart failure (ejection fraction < 55%)
4. Peripheral vascular disease,
5. Degenerative joint disease, musculoskeletal disease, or peripheral vascular disease
that limits ability to exercise
6. Know hypersensitivity to Definity® ultrasound contrast agent
7. Intra-cardiac or pulmonary shunt
8. The use of antithrombotic agents or a severe bleeding diathesis due to risk of
bleeding with intravenous and arterial line placement
9. Physical activity greater than three hours per week
10. Pregnancy
We found this trial at
1
site
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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