Pharmacokinetics and Safety of Alisporivir in Subjects With End Stage Renal Disease on Hemodialysis Compared to Healthy Subjects

Inclusion Criteria:

- Provides written informed consent before any assessment is performed

- Matched healthy participants are in good health as determined by past medical
history, physical examination, vital signs, laboratory tests, and other assessments

- ESRD participants are on a protocol-defined stable hemodialysis regimen and have no
evidence of hepatic decompensation, with vital signs and other tests within
protocol-specified limits

- Weighs at least 50 kg

- Is able to communicate well with the investigator, to understand and comply with the
requirements of the study.

Exclusion Criteria:

- Has history or current use of over-the-counter medications, dietary supplements, or
drugs (including nicotine and alcohol) outside protocol-specified parameters

- Has signs, symptoms or history of any condition that, per protocol or in the opinion
of the investigator, might compromise:

1. the safety or well-being of the participant or study staff;

2. the safety or well-being of the participant's offspring (such as through
pregnancy or breast-feeding);

3. the analysis of results