Mucosal Impedance and Eosinophilic Esophagitis



Status:Recruiting
Conditions:Gastrointestinal
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - 90
Updated:11/11/2018
Start Date:September 2013
End Date:July 2020

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Trial Summary
Trial Overview
Inclusion Criteria

Mucosal Impedance in Eosinophilic Esophagitis and the Effect of Treatment

Do patients with eosinophilic esophagitis have baseline increased esophageal mucosal
impedance?

And will treatment that reverses esophageal eosinophilia in patients, correct abnormalities
in mucosal impedance?


Inclusion criteria:

- Adults ages 18-90 undergoing clinically indicated upper endoscopy

- Patients with EoE, defined as dysphagia with histologic finding of greater than or
equal to 15 eosinophils per high powered field on esophageal biopsy despite at least 6
weeks of twice daily proton pump inhibitor therapy

- Patients undergoing clinically indicated upper endoscopy for indications other than
dysphagia or GERD with normal appearing esophageal mucosa.

Exclusion criteria:

- Medical conditions such as severe heart or lung disease that preclude safe performance
of endoscopy

- Patients with conditions known to be associated with esophageal eosinophilia,
including Crohn's disease, Churg-Strauss, achalasia, and hypereosinophilic syndrome

- Inability to read due to: Blindness, cognitive dysfunction, or English language
illiteracy
We found this trial at
1
site
Mayo Clinic Rochester
200 First Street SW
Rochester, Minnesota 55905
507-284-2511
Phone: 507-538-0367
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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Rochester, MN
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