Point Prevalence Study of Multidrug-Resistant Organism Carriage by Healthcare Personnel
| Status: | Completed |
|---|---|
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 9/12/2018 |
| Start Date: | September 13, 2013 |
| End Date: | January 13, 2017 |
Acquisition and transmission of MDROs in healthcare facilities is a major patient safety
problem, afflicting in particular the antibiotic-exposed and immunodeficient patient
populations. MDRO-colonized patients require isolation to reduce the risk of transmission to
other patients, and frequently develop infections from their colonizing organisms.
Most clinically relevant MDROs are carried in the gastrointestinal tract; thus perirectal
cultures are frequently the surveillance method used to screen for these pathogens.
Surveillance to identify MDRO colonization allows for anticipation and timely initiation of
effective treatment of patients who develop infection.
The precise modes of transmission within hospitals are not known, but contamination of the
hands of healthcare personnel, patient care equipment, and the healthcare environment are
thought to play major roles in transmitting MDRO. Suboptimal hand hygiene can lead to
transmission on the hands of staff to other patients or colonization of their own
gastrointestinal tract. Few studies have investigated intestinal colonization of healthcare
professionals. Transmission of bacteria by healthcare personnel is thought to occur primarily
via contaminated hands; we wonder whether gastrointestinal carriage by healthcare personnel
also plays a role in nosocomial spread.
This study will screen a self-referred convenience sample of 400 healthcare personnel who
have contact with patients or patient culture specimens for fecal carriage of MDRO at one
point in time. A control group of 400 NIH employees or contractors who do not have contact
with patients or patient specimens will also be screened. Samples will be linked to
questionnaires to assess the exposure of staff members to patients or culture specimens with
known MDRO colonization or infection. We will use molecular typing techniques to link
healthcare personnel isolates to patient or environmental isolates. Finally, the study will
be conducted in such a way as to preserve to the greatest extent possible the anonymity of
volunteers, using a system of alphanumeric identifiers and unmanned drop boxes for specimen
collection.
problem, afflicting in particular the antibiotic-exposed and immunodeficient patient
populations. MDRO-colonized patients require isolation to reduce the risk of transmission to
other patients, and frequently develop infections from their colonizing organisms.
Most clinically relevant MDROs are carried in the gastrointestinal tract; thus perirectal
cultures are frequently the surveillance method used to screen for these pathogens.
Surveillance to identify MDRO colonization allows for anticipation and timely initiation of
effective treatment of patients who develop infection.
The precise modes of transmission within hospitals are not known, but contamination of the
hands of healthcare personnel, patient care equipment, and the healthcare environment are
thought to play major roles in transmitting MDRO. Suboptimal hand hygiene can lead to
transmission on the hands of staff to other patients or colonization of their own
gastrointestinal tract. Few studies have investigated intestinal colonization of healthcare
professionals. Transmission of bacteria by healthcare personnel is thought to occur primarily
via contaminated hands; we wonder whether gastrointestinal carriage by healthcare personnel
also plays a role in nosocomial spread.
This study will screen a self-referred convenience sample of 400 healthcare personnel who
have contact with patients or patient culture specimens for fecal carriage of MDRO at one
point in time. A control group of 400 NIH employees or contractors who do not have contact
with patients or patient specimens will also be screened. Samples will be linked to
questionnaires to assess the exposure of staff members to patients or culture specimens with
known MDRO colonization or infection. We will use molecular typing techniques to link
healthcare personnel isolates to patient or environmental isolates. Finally, the study will
be conducted in such a way as to preserve to the greatest extent possible the anonymity of
volunteers, using a system of alphanumeric identifiers and unmanned drop boxes for specimen
collection.
Acquisition and transmission of MDROs in healthcare facilities is a major patient safety
problem, afflicting in particular the antibiotic-exposed and immunodeficient patient
populations. MDRO-colonized patients require isolation to reduce the risk of transmission to
other patients, and frequently develop infections from their colonizing organisms.
Most clinically relevant MDROs are carried in the gastrointestinal tract; thus perirectal
cultures are frequently the surveillance method used to screen for these pathogens.
Surveillance to identify MDRO colonization allows for anticipation and timely initiation of
effective treatment of patients who develop infection.
The precise modes of transmission within hospitals are not known, but contamination of the
hands of healthcare personnel, patient care equipment, and the healthcare environment are
thought to play major roles in transmitting MDRO. Suboptimal hand hygiene can lead to
transmission on the hands of staff to other patients or colonization of their own
gastrointestinal tract. Few studies have investigated intestinal colonization of healthcare
professionals. Transmission of bacteria by healthcare personnel is thought to occur primarily
via contaminated hands; we wonder whether gastrointestinal carriage by healthcare personnel
also plays a role in nosocomial spread.
This study will screen a self-referred convenience sample of 400 healthcare personnel who
have contact with patients or patient culture specimens for fecal carriage of MDRO at one
point in time. A control group of 400 NIH employees or contractors who do not have contact
with patients or patient specimens will also be screened. Samples will be linked to
questionnaires to assess the exposure of staff members to patients or culture specimens with
known MDRO colonization or infection. We will use molecular typing techniques to link
healthcare personnel isolates to patient or environmental isolates. Finally, the study will
be conducted in such a way as to preserve to the greatest extent possible the anonymity of
volunteers, using a system of alphanumeric identifiers and unmanned drop boxes for specimen
collection.
problem, afflicting in particular the antibiotic-exposed and immunodeficient patient
populations. MDRO-colonized patients require isolation to reduce the risk of transmission to
other patients, and frequently develop infections from their colonizing organisms.
Most clinically relevant MDROs are carried in the gastrointestinal tract; thus perirectal
cultures are frequently the surveillance method used to screen for these pathogens.
Surveillance to identify MDRO colonization allows for anticipation and timely initiation of
effective treatment of patients who develop infection.
The precise modes of transmission within hospitals are not known, but contamination of the
hands of healthcare personnel, patient care equipment, and the healthcare environment are
thought to play major roles in transmitting MDRO. Suboptimal hand hygiene can lead to
transmission on the hands of staff to other patients or colonization of their own
gastrointestinal tract. Few studies have investigated intestinal colonization of healthcare
professionals. Transmission of bacteria by healthcare personnel is thought to occur primarily
via contaminated hands; we wonder whether gastrointestinal carriage by healthcare personnel
also plays a role in nosocomial spread.
This study will screen a self-referred convenience sample of 400 healthcare personnel who
have contact with patients or patient culture specimens for fecal carriage of MDRO at one
point in time. A control group of 400 NIH employees or contractors who do not have contact
with patients or patient specimens will also be screened. Samples will be linked to
questionnaires to assess the exposure of staff members to patients or culture specimens with
known MDRO colonization or infection. We will use molecular typing techniques to link
healthcare personnel isolates to patient or environmental isolates. Finally, the study will
be conducted in such a way as to preserve to the greatest extent possible the anonymity of
volunteers, using a system of alphanumeric identifiers and unmanned drop boxes for specimen
collection.
- INCLUSION CRITERIA:
Healthcare personnel at the NIH CC who have contact with patients or patient culture
specimens will be eligible for study participation. The control group will consist of NIH
employees, contractors of the NIH, C or people who work on the Bethesda NIH campus without
exposure to patients or patient culture specimens.
EXCLUSION CRITERIA:
Individuals less than 18 years of age and those with any condition that, in the opinion of
the principal investigator or designee, contraindicates participation in the study will be
excluded.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
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