Effect of IV Acetaminophen on Patients in the Neurocritical Care Unit



Status:Completed
Conditions:Cardiology, Hospital, Neurology
Therapuetic Areas:Cardiology / Vascular Diseases, Neurology, Other
Healthy:No
Age Range:18 - 90
Updated:12/10/2016
Start Date:August 2013
End Date:November 2016

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Trial Summary
Trial Overview
Inclusion Criteria

To assess the efficacy of an intravenous nonnarcotic pain medication on controlling patient
pain.

To assess the effect of an intravenous nonnarcotic pain medication on patient sedation
levels in neurocritically ill patients.

To assess the effect of an intravenous nonnarcotic pain medication on common side effects
seen in patients taking other intravenous narcotic pain medication in the neurocritical care
unit.


Inclusion Criteria:

- > 45 kg (amenable to adult dosing)

- all traumatic brain injuries NPO for at least 12 hours

- all post-operative craniotomy patients

- all non-operative subarachnoid hemorrhage, intraparenchymal hemorrhage, and stroke
patients

- all carotid endarterectomy and carotid artery stenosis patients

- all endovascular patients undergoing intracranial intervention

- all post-op spine patients admitted to the NCCU

Exclusion Criteria:

- documented allergy to acetaminophen

- documented severe hepatic impairment (Child-Pugh score > 6) or severe hepatic disease
(hepatitis)

- documented severe renal impairment (CrCl < 30 ml/min) Blood tests will be performed
prior to study procedures that will ensure patients do not have renal impairment.

- patients who are pregnant or breast feeding
We found this trial at
1
site
University of Utah
201 Presidents Circle
Salt Lake City, Utah 84108
801) 581-7200
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