Effect of Perioperative Intravenous Lidocaine on Postoperative Quality of Recovery in Patients Undergoing Spine Surgery

Consented patients will be randomized to either saline group or lidocaine group. General
anesthesia will be induced as it would normally be done in any patient undergoing spine
surgery. Once the patient is positioned for the surgery bolus followed by the infusion of
either the study drug or the placebo will be administered. The infusion will be stopped at
the end of surgery and the patient will be transferred to the post anesthesia care unit.
Post operative pain score will be evaluated for the first 24 hrs and also the amount of pain
medications used will be recorded. At the end of 24 hours quality of recovery will be
assessed using a qor-40 questionnaire.

Inclusion Criteria:

1. Patients age 18-80 yrs;

2. American Society of Anesthesiology Physical Status I, II or III; and

3. Patients undergoing thoracic or lumbosacral spine surgeries with or without
instrumentation via the posterior approach with planned admission to the post
anesthesia care unit after surgery-

Exclusion Criteria:

1. Allergy to any of the study medications or anesthetic agents used in the study;

2. American Society of Anesthesiology physical status IV;

3. Spine surgery with the expected duration of surgery being more than 4 hours as
determined by the attending surgeon;

4. History of severe hepatic dysfunction with liver enzymes elevated to more than 3
times the normal or International normalized ratio of more than 2 and renal
dysfunction with GFR less than 60 ml/min

5. History of previous spinal fusion or instrumentation;

6. Diagnosis of cancer of the spine;

7. History of surgery for abscess or osteomyelitis;

8. History of cardiac dysrhythmia or heart block;

9. History of chronic heroin or methadone use;

10. Preoperative use of any systemic corticosteroid;

11. History of seizure disorder; and

12. Patient inability to properly describe postoperative pain to investigators (dementia,
delirium, psychiatric disorder).