A Phase II Trial to Examine the Effect of Subcutaneous Exenatide (Bydureon®) on Glucose Control in Patients With Type I Diabetes

This is a multi-site randomized placebo controlled trial of Bydureon in patients with type I
diabetes (T1D) of at least 2 years duration who may or may not still have detectable levels
of C-peptide during a mixed meal tolerance test (MMTT). Bydureon is a recently approved long
acting form of Exenatide. Because of the lack of safety data for Bydureon in children, we
propose to conduct the trial in adults (>18 yrs.).

Both the subject and the study personnel will be blinded to treatment assignment. The
randomization will be done, 1;1, by the coordinating site (at Yale). As a secondary analysis,
we propose to determine whether the presence of residual insulin production modifies the drug
effect. To do this, we plan to stratify patients for randomization on the basis of detectable
C-peptide levels. We will therefore wait for the results of the C-peptide levels from the
enrollment MMTT prior to randomization. The study investigators will not be told in which
stratum the patient is being randomized and will be blinded to the C-peptide results of the
MMTT until the conclusion of the study.

Note: The primary and study completion dates were changed 4/2016 to reflect an extension of
the recruitment and accrual periods.

Inclusion Criteria

- Male or female aged 18-65 years who meets the American Diabetes Association standard
T1DM criteria.

- Diagnosis of T1DM at least 2 years from Visit 0

- Insulin Requirement of ≤ 0.90 units/kg

- Absence of ketoacidosis in the past 6 months

- HbA1c of ≥ 6.5% and ≤ 9.5%

- Menstruating women must have a negative pregnancy test and be willing to avoid
pregnancy during the study period

- Signed informed consent

Exclusion Criteria:

- Inability or unwillingness to give informed consent

- Current or prior use of immunomodulators or systemic steroids in the last 6 months
that could potentially affect diabetes or immunologic status.

- Known hypersensitivity to Exenatide, Liraglutide or any product component.

- Participation in an investigational treatment trial within the last 6 weeks before
enrollment.

- 1 or more episodes of hypoglycemia (loss of consciousness or requiring the help of
others) within the last 6 months.

- Another condition that would, in the view of the investigator, affect the safety of
using Bydureon. This might include, among others a history of MEN 2, a history of
medullary carcinoma of the thyroid or pancreatitis.

- Known severe renal impairment, end-stage renal disease or renal transplantation.

- Any history of gastroparesis or other severe gastrointestinal disease, pancreatitis,
thyroid nodules or malignancy with the exclusion of a history of localized basal cell
carcinoma.

- Uncompensated heart failure, fluid overload, myocardial infarction or liver disease
within the last 6 weeks before enrollment.

- Clinically active serious infection.

- Positive pregnancy test in menstruating women or lactating females.

- Concurrent use of Pramlinitide, other Incretin medications, or other anti-diabetes
medications other than insulin.