Prilosec Bioequivalence Study in Healthy Volunteers

Inclusion Criteria:

- Healthy male and female volunteers aged 18 to 50 years, inclusive, with suitable
veins for cannulation or repeated venepuncture.

- Female could be of nonchildbearing potential (postmenopausal or irreversible surgical
sterilization) and childbearing potential (negative pregnancy test at screening and
use 2 effective methods of avoiding pregnancy).

- Have a body mass index (BMI) between 18 and 30 kg/m2, inclusive, and a weight of at
least 50 kg and no more than 100 kg, inclusive.

Exclusion Criteria:

- History of any clinically important disease or disorder which, in the opinion of the
Investigator, may either put the volunteer at risk because of participation in the
study.

- History or presence of gastrointestinal, hepatic, or renal disease or any other
condition known to interfere with absorption, distribution, metabolism, or excretion
of drugs.

- Any clinically important illness, medical/surgical procedure, or trauma within 4
weeks of the first administration of investigational medicinal product (IMP).

- Any clinically significant abnormalities in the physical examination, clinical
laboratory values, 12-lead ECG, or vital signs, as judged by the Investigator.

- Moderate to heavy smokers (more than 10 cigarettes per day or equivalent in
tobacco-containing products).