Protective Effects of Propranolol in Adults



Status:Recruiting
Conditions:Hospital
Therapuetic Areas:Other
Healthy:No
Age Range:18 - Any
Updated:9/13/2018
Start Date:July 2013
End Date:December 2019
Contact:Catherine Reed, RN
Email:ca2reed@utmb.edu
Phone:409-7706987

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Protective Effects of Propranolol in Adults Following Major Burn Injury: A Safety and Efficacy Trial

This efficacy and safety trial will examine the effects and safety of propranolol
administered to adult patients with severe burn injury. The investigators hypothesize that
propranolol will provide significant benefit to adults following severe burn injury at doses
that are safe and do not increase risk of adverse infectious and non-infectious outcomes.

A safety and efficacy trial is needed in order to determine the safety of propranolol
treatment in adult burn patients, identify which subpopulations may be most likely to benefit
from propranolol treatment and to identify propranolol dose levels that are not only safe but
potentially effective.

Inclusion Criteria:

- ≥ 20% Total Body Surface Area (TBSA) burn with anticipated operation need on admission

- Age ≥ 18 years

- Admission within 72 hours of injury

Exclusion Criteria:

- Age <18

- Patients unlikely to survive injury or with ;age = total burn size ≥ 130

- Electrical or deep chemical burn

- Malignancy currently undergoing treatment or history of cancer treatment within 5
years

- History of HIV or AIDS

- Presence of anoxic brain injury that is not expected to result in complete recovery

- Currently treated for Chronic Obstructive Pulmonary Disease (COPD), asthma or other
chronic pulmonary conditions

- History of Congestive Heart Failure (CHF) (ejection fraction < 20%)

- Pre-injury medications including blocking agents (alpha or beta) or other
anti-arrhythmic drugs

- Pregnant women

- Prisoners

- History of cardiac arrhythmia requiring medication

- Medical condition requiring glucocorticoid treatment

- Patients with concurrent conditions that in the opinion of the investigator may
compromise patient safety or study objectives
We found this trial at
10
sites
Maywood, Illinois 60153
Principal Investigator: Richard Gamelli, MD
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Principal Investigator: Shawn Fagan, MD
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Boston, MA
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Gainesville, Florida 32610
(352) 392-3261
Principal Investigator: David Mozingo, MD
University of Florida The University of Florida (UF) is a major, public, comprehensive, land-grant, research...
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Gainesville, FL
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301 University Blvd
Galveston, Texas 77555
(409) 772-1011
Principal Investigator: David Herndon, MD
Phone: 409-770-6731
University of Texas Medical Branch Established in 1891 as the University of Texas Medical Department,...
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Galveston, TX
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101 Jessup Hall
Iowa City, Iowa 52242
(319) 335-3500
Principal Investigator: G Patrick Kealey, MD
University of Iowa With just over 30,000 students, the University of Iowa is one of...
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Iowa City, IA
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Seattle, Washington 98104
(206) 543-2100
Principal Investigator: Tam Pham, MD
Univ of Washington Founded in 1861 by a private gift of 10 acres in what...
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Seattle, WA
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281 W. Lane Ave
Columbus, Ohio 43210
(614) 292-6446
Principal Investigator: Sidney Miller, MD
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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Columbus, OH
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Dallas, Texas 75390
Principal Investigator: Steven Wolf, MD
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Dallas, TX
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New York, New York 10065
Principal Investigator: Joe Bassey, MD
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New York, NY
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Toronto, Ontario
Principal Investigator: Marc Jeschke, MD
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Toronto,
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