To Assess the Safety and Efficacy of R932348 Ophthalmic Solutions in Patients With Keratoconjunctivitis Sicca

Inclusion Criteria:

- A history of dry eye (based on the date of initial dry eye symptoms)

- Use of over-the-counter (OTC) and/or prescription eye drops for dry eye symptoms

- Corneal fluorescein staining score of at least 2 in the inferior region

Exclusion Criteria:

- History of, or a concurrent clinically significant illness, medical condition (other
than Keratoconjunctivitis Sicca or Sjögren's syndrome), or laboratory abnormality
that, in the Investigator's opinion, could affect the conduct of the study.

- Use of ophthalmic cyclosporine within 45 days of Visit 1.

- Use of any topical ophthalmic steroid within 2 weeks of Visit 1.

- Have worn contact lenses or anticipate using contact lenses during the study.

- Have a condition or be in a situation that the Investigator feels may put the subject
at significant risk, may confound the study results, or may interfere significantly
with the subject's participation in the study.

- Have a history of alcohol or substance abuse that, in the judgment of the
Investigator, may impair or risk the subject's full participation in the study.