A Study to Characterize the Abuse Liability of Intravenous Oxycodone Alone or in Combination With Intravenous Naltrexone in Healthy, Non-Dependent, Recreational Opioid Users
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 10/3/2013 |
| Start Date: | July 2013 |
| End Date: | September 2013 |
| Contact: | Pfizer CT.gov Call Center |
| Phone: | 1-800-718-1021 |
A Randomized, Single-Dose, Placebo-Controlled, Double-Blind, 3-Way Crossover Study to Determine the Relative Abuse Potential of Intravenous Oxycodone Hydrochloride Alone or in Combination With Intravenous Naltrexone Hydrochloride in Opioid Experienced Non-Dependent Subjects
The main purpose of this study is to simulate if oxycodone and naltrexone combination
capsules (ALO-02) were to be tampered with by dissolving and then injecting intravenously
for the purpose of getting high.
Inclusion Criteria:
- Healthy subjects
- Non-dependent, recreational opioid users
- Must include at least one of these routes of administration: intranasal use on at
least 3 occassions in the past year or intravenous use on at least 1 occasion in the
past year before Screening (Visit 1).
Exclusion Criteria:
- Diagnosis of substance and/or alcohol dependence
- Subject has participated in, is currently participating in, or seeking treatment for
substance and/or alcohol related disorder
- History of sleep apnea.
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