Effect of Aerobic Interval Training on Cardiovascular Function in Type 2 Diabetes

Cardiovascular function will be measured at baseline in adults with type 2 diabetes and in
age-matched healthy controls. Research volunteers with type 2 diabetes who meet the inclusion
criteria will be randomized to the aerobic interval training group, continuous moderate
exercise group or non-exercise control group. At the end of the 8-week randomized control
exercise intervention, baseline measures will be repeated.

Inclusion Criteria for type 2 diabetes :

- Diagnosis of type 2 diabetes

- Sedentary or minimally physically active for at least the prior 1 year

- Able to give consent

Inclusion criteria for healthy control group:

- Sedentary or minimally physically active for at least the prior 1 year

- Able to give consent

Exclusion Criteria:

- History of diabetic proliferative retinopathy, autonomic or peripheral neuropathy

- History of any relevant cardiovascular diseases (myocardial infarction, angina
pectoris, history of coronary artery bypass surgery or angioplasty, congestive heart
failure, or arrhythmia)

- Hypertension (≥160 mmHg systolic or ≥100 mmHg diastolic)

- History of renal impairment

- History of gout or hyperuricemia

- History of hepatic disease or infection with hepatitis B, C

- History of seizures, or other relevant on-going or recurrent illness

- Recent (within 3 months) or recurrent hospitalizations

- Use of tobacco products

- >5 % weight change in the prior 6 months.

- Current intake of medications that may affect study results

- Premenopausal women taking oral contraceptives and postmenopausal women taking hormone
replacement therapy.

- Pregnancy (positive urine pregnancy test) or lactation

- For the healthy control group, history of diabetes.