The Effect of Obesity on Oral Peri-implant Health - A Cross-Sectional Study
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/5/2014 |
| Start Date: | June 2012 |
| Contact: | Lauren M Thomann |
| Email: | lauren-thomann@uiowa.edu |
| Phone: | 3193357377 |
In recent years, greater emphasis has been placed on the link between oral and systemic
health. Obesity, a growing medical problem worldwide, has been associated with multiple
chronic inflammatory diseases such as diabetes mellitus and cardiovascular disease. With
respect to the effect of obesity on periodontal health, it has been shown that obese
subjects exhibit higher inflammation around natural teeth and are at increased risk of tooth
loss than individuals with normal weight. Peri-implantitis, an inflammatory condition of
bacterial origin that occurs around oral implants and resembles periodontal disease, has
become a serious concern for the dental profession given its increasing prevalence and
challenging treatment. There is also strong evidence that individuals with a history of
periodontitis are also at risk for peri-implantitis. However, knowledge about the
pathogenesis and treatment of peri-implantitis is scarce. Hence, it is extremely important
to understand the implications of excessive body fat on peri-implant health. Based on the
current understanding on the effect of obesity on systemic and local inflammation around
natural teeth, the investigators hypothesize that obesity will have a significant impact on
peri-implant health by inducing an increased inflammatory response as measured by clinical
as well as molecular markers of inflammation.
health. Obesity, a growing medical problem worldwide, has been associated with multiple
chronic inflammatory diseases such as diabetes mellitus and cardiovascular disease. With
respect to the effect of obesity on periodontal health, it has been shown that obese
subjects exhibit higher inflammation around natural teeth and are at increased risk of tooth
loss than individuals with normal weight. Peri-implantitis, an inflammatory condition of
bacterial origin that occurs around oral implants and resembles periodontal disease, has
become a serious concern for the dental profession given its increasing prevalence and
challenging treatment. There is also strong evidence that individuals with a history of
periodontitis are also at risk for peri-implantitis. However, knowledge about the
pathogenesis and treatment of peri-implantitis is scarce. Hence, it is extremely important
to understand the implications of excessive body fat on peri-implant health. Based on the
current understanding on the effect of obesity on systemic and local inflammation around
natural teeth, the investigators hypothesize that obesity will have a significant impact on
peri-implant health by inducing an increased inflammatory response as measured by clinical
as well as molecular markers of inflammation.
Inclusion Criteria:
- Adults (18 years or older)
- Currently non-smokers
- Subjects in maintenance care with adequate dental plaque control (<20% plaque index
according to O'Leary et al. 1972)
- Subjects with at least one rough surface titanium oral implant in function for at
least 6 months.
Exclusion Criteria:
- Edentulous subjects or subjects presenting with blade-type implants and/or implants
with smooth surface.
- Pregnant or nursing women
- Subjects who have taken medications that are known to alter the oral inflammatory
status, such as antibiotics and anti-inflammatory agents, for 3 months prior to the
study.
- Subjects with a history of aggressive periodontitis (As defined by the American
Academy of Periodontology).
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