Post-approval Study of The Glaukos® iStent® Trabecular Micro-bypass Stent: Extended Follow-up of the Premarket Cohort

The goal of this study was to demonstrate that use of this device in conjunction with
cataract surgery did not result in a rate of sight-threatening adverse events, after 5 years
of implantation that was higher than the rate of sight-threatening adverse events that
occurred after cataract surgery alone, by more than a non-inferiority margin of 5%.

Inclusion Criteria:

- Subjects previously enrolled in Glaukos Study GC-003 who are able and willing to
participate in this extended follow-up study

Exclusion Criteria:

- Subjects previously enrolled in Glaukos Study GC-003 who are not able or willing to
participate in this extended follow-up study

- Patients not previously enrolled in Glaukos Study GC-003