Leptin Biology in Adipose Tissue
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 4/21/2016 |
| Start Date: | August 2011 |
| End Date: | July 2018 |
| Contact: | Somers_CPL Lab |
| Email: | CPL@mayo.edu |
Leptin is a fat hormone which acts in maintaining energy balance. However, leptin levels are
high in obese subjects indicating resistance to the actions of leptin. High leptin levels
have been associated with increased cardiovascular and metabolic risks, but it is not clear
if increased leptin or leptin resistance contributes to the increased cardiovascular risk.
Further, even though leptin receptors are present in fat tissue, leptin's role in fat tissue
functions are not completely investigated in humans. Based on preliminary data the
investigators hypothesize that resistance to leptin action in obese adipose tissue is
responsible for altering the expression of adipose tissue proteins which contribute to the
development of cardiovascular and metabolic dysfunction. To test this hypothesis the
investigators propose a novel study directed at investigating the leptin dependent changes
in adipose tissue protein expression using adipose tissue obtained from lean and obese human
subjects
high in obese subjects indicating resistance to the actions of leptin. High leptin levels
have been associated with increased cardiovascular and metabolic risks, but it is not clear
if increased leptin or leptin resistance contributes to the increased cardiovascular risk.
Further, even though leptin receptors are present in fat tissue, leptin's role in fat tissue
functions are not completely investigated in humans. Based on preliminary data the
investigators hypothesize that resistance to leptin action in obese adipose tissue is
responsible for altering the expression of adipose tissue proteins which contribute to the
development of cardiovascular and metabolic dysfunction. To test this hypothesis the
investigators propose a novel study directed at investigating the leptin dependent changes
in adipose tissue protein expression using adipose tissue obtained from lean and obese human
subjects
Inclusion Criteria:
1. Age 18-75 years
2. BMI BMI ≤25 (lean) or >30 kg/m2 (obese)
3. Going to undergo a surgical procedure where omental and subcutaneous adipose tissue
may be biopsied.
Exclusion Criteria:
Inability to provide written informed consent.
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