The Effect of Mixed Exercise and Metabolic Stress in Relationship to Age in Healthy Men
| Status: | Recruiting |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 5/3/2014 |
| Start Date: | February 2013 |
| Contact: | Jean Wigham, RN |
| Email: | Wigham.Jean@Mayo.edu |
| Phone: | 507-293-1188 |
The Effect of Mixed Exercise and Metabolic Stress Upon Pituitary Secretion in Relationship to Age in Healthy Men: a Pilot Study
Aging in men reduces the amount of luteinizing hormone (LH) and testosterone (Te) secreted
in each burst. Stress-associated mechanisms introduced by acute illness and chronic
disease decrease LH and Te secretion further. A major unresolved issue is whether the
aging process heightens the negative effects of a stressor (whether physical or metabolic)
upon LH and Te secretion. This study will assess LH and Te secretion in response to a
physical stressor (maximal exercise) and a common metabolic stressor (hyperglycemia) as a
function of age in healthy men ages 18-80 yr.
in each burst. Stress-associated mechanisms introduced by acute illness and chronic
disease decrease LH and Te secretion further. A major unresolved issue is whether the
aging process heightens the negative effects of a stressor (whether physical or metabolic)
upon LH and Te secretion. This study will assess LH and Te secretion in response to a
physical stressor (maximal exercise) and a common metabolic stressor (hyperglycemia) as a
function of age in healthy men ages 18-80 yr.
Inclusion Criteria:
- Community dwelling, healthy men age 18 to 80
- Body-Mass Index (BMI) 18-30 kg/m2
- Willingness to provide written informed consent
- Physician acceptable screening ECG for participants 60 years and older
Exclusion Criteria:
- recent use of psychotropic or neuroactive drugs (within five biological half-live)
- obesity (outside weight range above)
- acute weight change (loss or gain of >2 kg in 6 weeks
- Laboratory test results not deemed physician acceptable
- triglycerides > 300
- BUN >30
- creatinine > 1.5 mg/dL
- liver functions tests twice upper limit of normal
- electrolyte abnormality
- anemia; hemoglobin < 12.0 gm/dL
- drug or alcohol abuse
- psychosis, depression, mania or severe anxiety
- acute or chronic organ-system disease
- endocrinopathy, other than primary thyroidal failure receiving replacement
- untreated osteoporosis
- nightshift work or recent transmeridian travel (exceeding 3 time zones within 7 days
of admission)
- PSA > 4.0 ng/mL, History or suspicion of prostatic disease (elevated
PSA,indeterminate nodule or mass, obstructive uropathy)
- History of carcinoma (excluding localized basal cell carcinoma removed or surgically
treated with no recurrence
- History of thrombotic arterial disease (stroke, TIA, MI, angina) or deep vein
thrombophlebitis
- History of CHF, cardiac arrhythmias, congential QT prolongation, and medications used
to treat cardiac arrhythmias
- Gynecomastia > 2 cm, untreated
- Untreated gallbladder disease
- History of smoking greater than one ppd.
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