A Study of Brentuximab Vedotin in Relapsed or Refractory Non-Hodgkin Lymphoma



Status:Recruiting
Conditions:Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:6 - Any
Updated:2/7/2015
Start Date:August 2011
End Date:January 2017
Contact:Terri Lowe
Email:clinicaltrials@seagen.com
Phone:866-333-7436

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A Phase 2 Study of Brentuximab Vedotin in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL)

This is an open-label, multicenter, phase 2 clinical trial to evaluate the efficacy and
safety of brentuximab vedotin as a single agent in patients with CD30-positive non-Hodgkin
lymphoma (NHL) (Part A). The study will also evaluate the safety and efficacy of
brentuximab vedotin in combination with rituximab in patients with relapsed or refractory
diffuse large B-cell lymphoma (DLBCL) (Part B) as well as further evaluate correlation of
CD30 expression and response in DLBCL (Part C).


Inclusion Criteria:

- Histologically-confirmed NHL (DLBCL only for Parts B and C)

- Relapsed or refractory disease following at least 1 prior systemic therapy

- Measurable disease of at least 1.5 cm as documented by CT

- ECOG performance status less than or equal to 2

Exclusion Criteria:

- History of another primary invasive malignancy that has not been in remission for at
least 3 years

- Current diagnosis of systemic or cutaneous anaplastic large cell lymphoma or mycosis
fungoides

- B cell lymphoma previously treated with only single-agent rituximab (for patients
receiving brentuximab vedotin only) or corticosteroids as monotherapy

- Known cerebral/meningeal disease
We found this trial at
33
sites
875 Blake Wilbur Dr
Stanford, California 94305
(650) 498-6000
Stanford University Cancer Institute The Stanford Cancer Institute (SCI) focuses the world-class expertise of more...
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Stanford, CA
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Birmingham, AL
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201 East Huron Street
Chicago, Illinois 60611
(847) 491-3741
Northwestern University Northwestern is recognized both nationally and internationally for the quality of its educational...
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Chicago, IL
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
University of Chicago One of the world's premier academic and research institutions, the University of...
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Chicago, IL
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1275 York Avenue
New York, New York 10065
212-639-2000
Memorial Sloan-Kettering Cancer Center Memorial Sloan-Kettering Cancer Center — the world's oldest and largest private...
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New York, NY
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Albany, New York 12206
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Atlanta, Georgia 30322
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450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston, MA
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171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Cleveland, Ohio 44195
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Dallas, Texas 75246
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1721 East 19th Ave., Suite #200 & #300
Denver, Colorado 80218
720-754-4800
Colorado Blood Cancer Institute When patients come to the Colorado Blood Cancer Institute, the entire...
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1500 East Duarte Road
Duarte, California 91010
626-256-HOPE (4673)
City of Hope National Medical Center City of Hope is dedicated to making a difference...
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Edmonds, Washington 98026
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Eugene, OR
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8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
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Fort Worth, Texas 76132
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Greenville, South Carolina 29601
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30 Prospect Ave
Hackensack, New Jersey 07601
(201) 996-2000
Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
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Houston, TX
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9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
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Minneapolis, Minnesota 55405
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630 W 168th St
New York, New York
212-305-2862
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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New York, New York 10016
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Oxnard, CA
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Round Rock, Texas 78665
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660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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Tyler, Texas 75702
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Vancouver, Washington 98684
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