Cetuximab and/or Bevacizumab Combined With Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer
Status: | |
---|---|
Conditions: | Colorectal Cancer, Cancer |
Therapuetic Areas: | Oncology |
Healthy: | No |
Age Range: | Any |
Updated: | 8/15/2012 |
Start Date: | November 2005 |
A Phase III Trial of Irinotecan / 5-FU / Leucovorin or Oxaliplatin / 5-FU/ Leucovorin With Bevacizumab, or Cetuximab (C225), or With the Combination of Bevacizumab and Cetuximab for Patients With Untreated Metastatic Adenocarcinoma of the Colon or Rectum
RATIONALE: Monoclonal antibodies, such as cetuximab and bevacizumab, can block tumor growth
in different ways. Some block the ability of tumor cells to grow and spread. Others find
tumor cells and help kill them or carry tumor-killing substances to them. Cetuximab may also
stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor.
Drugs used in chemotherapy, such as fluorouracil, leucovorin, oxaliplatin, and irinotecan,
work in different ways to stop the growth of tumor cells, either by killing the cells or by
stopping them from dividing. Giving monoclonal antibodies together with combination
chemotherapy may kill more tumor cells. It is not yet known whether combination chemotherapy
is more effective with cetuximab and/or bevacizumab in treating patients with colorectal
cancer.
PURPOSE: This randomized phase III trial is studying cetuximab and/or bevacizumab when given
together with combination chemotherapy to compare how well they work in treating patients
with metastatic colorectal cancer.
OBJECTIVES:
Primary
- Compare overall survival of patients with previously untreated metastatic colorectal
cancer treated with cetuximab and/or bevacizumab in combination with either
oxaliplatin, fluorouracil, and leucovorin calcium (FOLFOX) OR irinotecan hydrochloride,
fluorouracil, and leucovorin calcium (FOLFIRI). (Arm III [cetuximab and bevacizumab in
combination with FOLFOX or FOLFIRI] closed to accrual as of 09/10/2009)
Secondary
- Compare response, progression-free survival, time to treatment failure, and duration of
response in patients with unresectable disease treated with these regimens.
- Compare toxicity and 60-day survival of patients with unresectable disease treated with
these regimens.
- Determine whether patients with unresectable disease become eligible for surgical
resection after treatment with these regimens.
OUTLINE: This is a randomized, open-label, multicenter study. Patients are stratified
according to physician-selected chemotherapy (oxaliplatin, leucovorin calcium, and
fluorouracil [FOLFOX] vs irinotecan hydrochloride, leucovorin calcium, or fluorouracil
[FOLFIRI]), prior adjuvant chemotherapy (yes vs no), and prior pelvic radiotherapy (yes vs
no). Patients are randomized to 1 of 3 treatment arms. (Arm III closed to accrual as of
09/10/2009)
- Arm I: Patients receive oxaliplatin IV over 2 hours or irinotecan hydrochloride IV over
30-90 minutes; leucovorin calcium IV over 2 hours; fluorouracil IV continuously over
46-48 hours; and bevacizumab IV over 30-90 minutes on days 1, 15, 29, and 43.
- Arm II: Patients receive oxaliplatin or irinotecan hydrochloride, leucovorin calcium,
and fluorouracil as in arm I. Patients also receive cetuximab IV over 1-2 hours on days
1, 8, 15, 22, 29, 36, 43, and 50.
- Arm III (closed to accrual as of 09/10/2009): Patients receive oxaliplatin or
irinotecan hydrochloride, leucovorin calcium, fluorouracil, and bevacizumab as in arm
I. Patients also receive cetuximab as in arm II.
In all arms, treatment repeats every 56 days for at least 2 courses in the absence of
disease progression, unacceptable toxicity, or planned surgery with curative intent.
For patients whom elective surgery is contemplated, bevacizumab must be discontinued for at
least 8 weeks before surgery and may not be resumed for at least 4 weeks after surgery.
Patients who undergo complete resection of metastatic disease are removed from study.
After completion of study treatment, patients are followed up every 2 months for 5 years and
then every 6 months for 5 years.
PROJECTED ACCRUAL: A total of 2,900 patients will be accrued for this study.
DISEASE CHARACTERISTICS:
- Histologically or cytologically confirmed adenocarcinoma of the colon or rectum
- Locally advanced (unresectable) or metastatic disease
- Patients with resected primary tumors who have documented metastases are
eligible
- Separate histological or cytological confirmation is not required from
patients with a history of colorectal cancer (previously treated by
surgical resection) who have now developed radiological or clinical
evidence of metastatic disease, unless 1 of the following is true:
- An interval of > 5 years has elapsed between the primary surgery and
the development of metastatic disease
- The primary cancer was stage I
- Patient must have a wildtype K-ras gene determined by the SWOG Solid Tumor Repository
laboratory or by local CLIA-certified laboratory
- Patients with a mutation in the K-ras gene not allowed
- The intent of this treatment must be indicated as follows:
- Palliative or neoadjuvant treatment with the potential for resection of all
sites of metastatic disease
- At least 1 paraffin block of previously resected primary tumor or tumor deposit
available
- Patients must have a wildtype K-ras gene
- No known CNS metastases or carcinomatous meningitis
PATIENT CHARACTERISTICS:
Performance status
- ECOG 0-1
Life expectancy
- Not specified
Hematopoietic
- Granulocyte count ≥ 1,500/mm^3
- Platelet count ≥ 100,000/mm^3
- Hemoglobin ≥ 9.0 g/dL (transfusion allowed)
- No history of significant bleeding episodes (e.g., hemoptysis or upper or lower
gastrointestinal bleeding) within the past 6 months unless the source of bleeding has
been resected
Hepatic
- Bilirubin ≤ 1.5 mg/dL
- Albumin ≥ 2.5 g/dL
- No evidence of Gilbert's syndrome for patients assigned to receive FOLFIRI
chemotherapy
- Gilbert's syndrome allowed for patients assigned to receive FOLFOX chemotherapy
Renal
- Creatinine ≤ 1.5 times upper limit of normal
- Protein < 1+ by urinalysis
- Protein < 1 g by 24-hour urine collection for patients with protein ≥ 2+ by
urinalysis
Cardiovascular
- No arterial thromboembolic events within the past 6 months, including any of the
following:
- Myocardial infarction
- Transient ischemic attack
- Cerebrovascular accident
- Unstable angina or angina requiring surgical or medical intervention
- No uncontrolled hypertension (i.e., blood pressure ≥ 160/90 on a regimen of
antihypertensive therapy)
- No New York Heart Association class II-IV congestive heart failure
- No clinically significant peripheral artery disease (i.e., claudication on less than
1 block)
Pulmonary
- No interstitial pneumonia
- No extensive or symptomatic interstitial fibrosis of the lung
- No pleural effusion or ascites that causes ≥ grade 2 dyspnea
Gastrointestinal
- No gastrointestinal perforation within past year
- No uncontrolled, predisposing colonic or small bowel disorder (i.e., > 3 watery or
soft stools daily for patients without a colostomy or ileostomy)
- Patients with a colostomy or ileostomy are eligible at the discretion of the
investigator
Neurologic
- No sensory peripheral neuropathy ≥ grade 2 for patients assigned to receive FOLFOX
chemotherapy
- No uncontrolled seizure disorder
- No active neurological disease
Other
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception during and for at least 2-6 months
after completion of study treatment
- No serious nonhealing wound, ulcer, or bone fracture
- No known hypersensitivity to Chinese hamster ovary cell products or recombinant human
or murine antibodies
- No other malignancy within the past 5 years except adequately treated basal cell or
squamous cell skin cancer or carcinoma in situ of the cervix
PRIOR CONCURRENT THERAPY:
Biologic therapy
- No prior agents that target vascular endothelial growth factor (VEGF) or EGF
receptors including protein products, monoclonal antibodies, or antisense therapies
- No prior bevacizumab or cetuximab
- No concurrent prophylactic filgrastim (G-CSF), pegfilgrastim, or sargramostim
(GM-CSF)
Chemotherapy
- See Radiotherapy
- More than 12 months since prior adjuvant chemotherapy (≤ 6 months in duration) that
included fluorouracil alone or in combination with oxaliplatin or irinotecan
hydrochloride
- No prior regional chemotherapy (e.g., hepatic arterial infusion)
- No other concurrent chemotherapy
Endocrine therapy
- No concurrent hormonal therapy except steroids for adrenal failure, hormones for
noncancer-related conditions (e.g., insulin for diabetes), or intermittent
dexamethasone as an antiemetic
Radiotherapy
- Prior radiotherapy with radiosensitizing chemotherapy allowed
- Prior standard adjuvant chemoradiotherapy for rectal cancer allowed
- At least 4 weeks since prior radiotherapy
- No prior radiotherapy to > 25% of bone marrow
- No concurrent palliative radiotherapy except whole brain irradiation for documented
CNS disease
Surgery
- See Disease Characteristics
- At least 4 weeks since prior major surgery
- At least 2 weeks since prior minor surgery
- Insertion of a vascular access device is not considered a prior surgery
- Recovered from all prior surgery
Other
- At least 4 weeks since prior itraconazole or ketoconazole
- No prior tyrosine kinase inhibitor therapy
- No prior systemic treatment for advanced or metastatic colorectal cancer
- No concurrent aprepitant
- Concurrent full-dose anticoagulation (i.e., warfarin) allowed provided all of the
following criteria are met:
- In-range INR (usually 2-3) on a stable dose of oral anticoagulant or stable dose
of low molecular weight heparin
- No active bleeding
- No pathological condition with a high risk of bleeding (e.g., tumor involving
major vessels or known varices)
- Concurrent antiplatelet agents allowed
- Concurrent daily prophylactic aspirin or anticoagulation for atrial fibrillation
allowed
We found this trial at
654
sites
100 Provena Way
Kankakee, Illinois 60914
Kankakee, Illinois 60914
815.937.8780
Provena St. Mary's Regional Cancer Center - Kankakee For over 20 years, Presence St. Mary's...
Click here to add this to my saved trials
1200 Old York Road
Abington, Pennsylvania 19001
Abington, Pennsylvania 19001
(215) 481-2400
Rosenfeld Cancer Center at Abington Memorial Hospital As one of the most trusted cancer centers...
Click here to add this to my saved trials
1200 S Cedar Crest Blvd
Allentown, Pennsylvania 18103
Allentown, Pennsylvania 18103
(610) 402-8000
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest Lehigh Valley Hospital provides a...
Click here to add this to my saved trials
Mission Hospitals - Memorial Campus Mission Health, based in Asheville, North Carolina, is the state
Click here to add this to my saved trials
Harold Alfond Center for Cancer Care MaineGeneral's Harold Alfond Center for Cancer Care (HACCC) is...
Click here to add this to my saved trials
Click here to add this to my saved trials
450 Brookline Ave
Boston, Massachusetts 2215
Boston, Massachusetts 2215
(617) 632-3000
Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute Founded in 1997, Dana-Farber/Harvard Cancer Center (DF/HCC) was...
Click here to add this to my saved trials
Olympic Hematology and Oncology We provide outpatient cancer services in a refined environment designed specifically...
Click here to add this to my saved trials
111 Colchester Ave
Burlington, Vermont 05401
Burlington, Vermont 05401
(802) 847-0000
Fletcher Allen Health Care - University Health Center Campus As Vermont
Click here to add this to my saved trials
1025 Morehead Medical Dr # 600
Charlotte, North Carolina 28204
Charlotte, North Carolina 28204
(704) 355-2884
Blumenthal Cancer Center at Carolinas Medical Center As our patients wage their personal wars against...
Click here to add this to my saved trials
200 Hawthorne Lane
Charlotte, North Carolina 28233
Charlotte, North Carolina 28233
704-384-4000
Presbyterian Cancer Center at Presbyterian Hospital At Novant Health Presbyterian Medical Center, we are welcoming...
Click here to add this to my saved trials
1300 Jefferson Park Avenue
Charlottesville, Virginia 22908
Charlottesville, Virginia 22908
434-243-6784
University of Virginia Cancer Center We are fortunate in having state of the art clinical...
Click here to add this to my saved trials
5841 S Maryland Ave # Mc1140
Chicago, Illinois 60637
Chicago, Illinois 60637
1-773-702-6180
University of Chicago Cancer Research Center The University of Chicago Comprehensive Cancer Center (UCCCC) is...
Click here to add this to my saved trials
675 N Saint Clair St # 21-100
Chicago, Illinois 60611
Chicago, Illinois 60611
(312) 695-1156
Robert H. Lurie Comprehensive Cancer Center at Northwestern University The cancer center was first established...
Click here to add this to my saved trials
Cleveland Clinic Taussig Cancer Center At Taussig Cancer Institute, more than 250 highly skilled doctors,...
Click here to add this to my saved trials
2500 Metrohealth Dr # C2100
Cleveland, Ohio 44109
Cleveland, Ohio 44109
(216) 778-5802
MetroHealth Cancer Care Center at MetroHealth Medical Center At the MetroHealth Cancer Care Center, we...
Click here to add this to my saved trials
115 Business loop 70 w
Columbia, Missouri 65203
Columbia, Missouri 65203
(573) 882-2100
Ellis Fischel Cancer Center at University of Missouri - Columbia At Ellis Fischel Cancer Center,...
Click here to add this to my saved trials
300 West 10th Avenue, Suite 519
Columbus, Ohio 43210
Columbus, Ohio 43210
614-293-5066
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University...
Click here to add this to my saved trials
3535 Olentangy River Road
Columbus, Ohio 43214
Columbus, Ohio 43214
(614) 566-5000
Riverside Methodist Hospital Cancer Care Serving central Ohio since 1892, Riverside Methodist is consistently ranked...
Click here to add this to my saved trials
100 North Academy Ave
Danville, Pennsylvania 17822
Danville, Pennsylvania 17822
570-271-6211
Geisinger Cancer Institute at Geisinger Health Since 1915, Geisinger Medical Center has been known as...
Click here to add this to my saved trials
1719 East 19th Avenue
Denver, Colorado 80218
Denver, Colorado 80218
(303) 839-6000
Presbyterian - St. Luke's Medical Center Presbyterian/St. Luke's Medical Center and the Rocky Mountain Hospital...
Click here to add this to my saved trials
Barbara Ann Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
Click here to add this to my saved trials
City of Hope Comprehensive Cancer Center City of Hope is a leading research and treatment...
Click here to add this to my saved trials
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
Click here to add this to my saved trials
11143 Parkview Plaza Dr # 100
Fort Wayne, Indiana 46845
Fort Wayne, Indiana 46845
(260) 484-8830
Fort Wayne Medical Oncology and Hematology Fort Wayne Medical Oncology and Hematology provides state-of-the-art cancer...
Click here to add this to my saved trials
2700 Wayne Memorial Drive
Goldsboro, North Carolina 27534
Goldsboro, North Carolina 27534
(919) 736-1110
Wayne Memorial Hospital, Incorporated Wayne Memorial Hospital, an affiliate of Wayne Health Corporation, is home...
Click here to add this to my saved trials
1920 Libal Street
Green Bay, Wisconsin 54307
Green Bay, Wisconsin 54307
(920) 433-8889
St. Vincent Hospital Regional Cancer Center Our group of 19 oncologists, including the region's only...
Click here to add this to my saved trials
19229 Mack Ave
Grosse Pointe Woods, Michigan 48236
Grosse Pointe Woods, Michigan 48236
(866) 246-4673
Van Elslander Cancer Center at St. John Hospital and Medical Center We built the Van...
Click here to add this to my saved trials
85 Retreat Ave # 2
Hartford, Connecticut 06102
Hartford, Connecticut 06102
Click here to add this to my saved trials
Cancer Research Center of Hawaii The University of Hawaii Cancer Center is the only National...
Click here to add this to my saved trials
St. Vincent Indianapolis Hospital At St.Vincent Indianapolis, everything we do begins with a focus on...
Click here to add this to my saved trials
200 Hawkins Drive
Iowa City, Iowa 52242
Iowa City, Iowa 52242
800-237-1225
Holden Comprehensive Cancer Center at University of Iowa Holden Comprehensive Cancer Center is dedicated to...
Click here to add this to my saved trials
University of Mississippi Cancer Clinic he Cancer Institute is home to the ACT Tobacco Treatment,...
Click here to add this to my saved trials
Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
Click here to add this to my saved trials
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
Click here to add this to my saved trials
Charles F. Kettering Memorial Hospital Our flagship hospital, Kettering Medical Center, stands proudly in Kettering,...
Click here to add this to my saved trials
Kinston Medical Specialists offers comprehensive medical services for all ages. Whether it’s a case of...
Click here to add this to my saved trials
1900 South Avenue
La Crosse, Wisconsin 54601
La Crosse, Wisconsin 54601
(608) 782-7300
Gundersen Lutheran Center for Cancer and Blood Gundersen Health System is where caring meets excellence...
Click here to add this to my saved trials
Click here to add this to my saved trials
1800 West Charleston Boulevard
Las Vegas, Nevada 89102
Las Vegas, Nevada 89102
(702) 383-2000
University Medical Center of Southern Nevada University Medical Center is dedicated to providing the highest...
Click here to add this to my saved trials
One Medical Center Drive
Lebanon, New Hampshire 03756
Lebanon, New Hampshire 03756
(603) 653-9000
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center Norris Cotton Cancer Center at DHMC in...
Click here to add this to my saved trials
902 Savannah Road
Lewes, Delaware 19958
Lewes, Delaware 19958
(302) 645-3770
Tunnell Cancer Center at Beebe Medical Center The Robert & Eolyne Tunnell Cancer Center at...
Click here to add this to my saved trials
Medical Center of Central Georgia Navicent Health is a designated Level I Trauma Center and...
Click here to add this to my saved trials
600 Highland Ave.
Madison, Wisconsin 53792
Madison, Wisconsin 53792
(608) 262-5223
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center UW Carbone Cancer Center holds the...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
1415 E. Kincaid
Mount Vernon, Washington 98273
Mount Vernon, Washington 98273
360-424-4111
Skagit Valley Hospital Cancer Care Center We know that treatment takes its toll physically, emotionally...
Click here to add this to my saved trials
800 NE 10th Street
Oklahoma City, Oklahoma 73104
Oklahoma City, Oklahoma 73104
(855) 750-2273
Oklahoma University Cancer Institute The Peggy and Charles Stephenson Cancer Center is located on the...
Click here to add this to my saved trials
985950 Nebraska Medical Center
Omaha, Nebraska 68198
Omaha, Nebraska 68198
402-559-4090
UNMC Eppley Cancer Center at the University of Nebraska Medical Center The Fred & Pamela...
Click here to add this to my saved trials
2501 N Orange Ave # 235
Orlando, Florida 32804
Orlando, Florida 32804
(407) 303-1700
Florida Hospital Cancer Institute at Florida Hospital Orlando FHCI is the largest cancer center in...
Click here to add this to my saved trials
Click here to add this to my saved trials
3181 SW Sam Jackson Park Rd
Portland, Oregon 97239
Portland, Oregon 97239
(503) 494-5058
Knight Cancer Institute at Oregon Health and Science University Cancer takes many forms. Although cancer...
Click here to add this to my saved trials
19500 10th Ave NE # 100
Poulsbo, Washington 98370
Poulsbo, Washington 98370
(360) 598-7500
Harrison Poulsbo Hematology and Onocology Harrison Poulsbo's new Hematology & Oncology center provides outpatient cancer...
Click here to add this to my saved trials
401 College Street
Richmond, Virginia 23298
Richmond, Virginia 23298
(804) 828-0450
Virginia Commonwealth University Massey Cancer Center Founded in 1974, VCU Massey Cancer Center is a...
Click here to add this to my saved trials
601 Elmwood Avenue
Rochester, New York 14642
Rochester, New York 14642
(585) 275-5830
James P. Wilmot Cancer Center at University of Rochester Medical Center The Wilmot Cancer Center...
Click here to add this to my saved trials
280 W MacArthur Blvd,
Sacramento, California 94611
Sacramento, California 94611
(510) 752-1000
Kaiser Permanente Medical Center - Oakland The East Bay area, home of the flagship Oakland...
Click here to add this to my saved trials
2279 45th Street
Sacramento, California 95817
Sacramento, California 95817
(916) 734-5800
University of California Davis Cancer Center At UC Davis Comprehensive Cancer Center, specialized teams of...
Click here to add this to my saved trials
660 S Euclid Ave #8100
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5196
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis The Alvin J. Siteman Cancer Center...
Click here to add this to my saved trials
4502 Medical Drive
San Antonio, Texas 78284
San Antonio, Texas 78284
(210) 567-7000
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
Click here to add this to my saved trials
1600 Divisadero Street
San Francisco, California 94115
San Francisco, California 94115
888.689.8273
UCSF Helen Diller Family Comprehensive Cancer Center UCSF’s long tradition of excellence in cancer research...
Click here to add this to my saved trials
700 Lawrence Expressway
Santa Clara, California 95051
Santa Clara, California 95051
Click here to add this to my saved trials
4700 Waters Avenue
Savannah, Georgia 31404
Savannah, Georgia 31404
912-350-8490
Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center The Curtis and...
Click here to add this to my saved trials
Group Health Central Hospital Group Health Cooperative is a member-governed, nonprofit health care system that...
Click here to add this to my saved trials
747 Broadway
Seattle, Washington 98122
Seattle, Washington 98122
206-386-6000
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus Since 1910, Swedish has...
Click here to add this to my saved trials
1959 NE Pacific St
Seattle, Washington 98195
Seattle, Washington 98195
(206) 598-4100
University Cancer Center at University of Washington Medical Center The Division of Radiation Oncology's work...
Click here to add this to my saved trials
Avera Cancer Institute Avera, the health ministry of the Benedictine and Presentation Sisters, is a...
Click here to add this to my saved trials
1305 West 18th Street
Sioux Falls, South Dakota 57117
Sioux Falls, South Dakota 57117
(605) 328-8000
Sanford Cancer Center at Sanford USD Medical Center Sanford Health is an integrated health system...
Click here to add this to my saved trials
Click here to add this to my saved trials
105 West 8th Avenue
Spokane, Washington 99220
Spokane, Washington 99220
(509) 474-3131
Providence Cancer Center at Sacred Heart Medical Center When Mother Joseph and the Sisters of...
Click here to add this to my saved trials
601 South Sherman Street
Spokane, Washington 99202
Spokane, Washington 99202
(509) 228-1000
Cancer Care Northwest - Spokane South Cancer Care Northwest is the Inland Northwest’s premier cancer...
Click here to add this to my saved trials
SUNY Upstate Medical University Hospital SUNY Upstate Medical University in Syracuse, NY, is the only...
Click here to add this to my saved trials
1717 S J St
Tacoma, Washington 98405
Tacoma, Washington 98405
(253) 426-4101
Franciscan Cancer Center at St. Joseph Medical Center St. Joseph Medical Center is a 361-bed...
Click here to add this to my saved trials
42 E Laurel Rd # 2545
Voorhees, New Jersey 08043
Voorhees, New Jersey 08043
(800) 826-6737
Cancer Institute of New Jersey at Cooper - Voorhees Cooper University Health Care, the clinical...
Click here to add this to my saved trials
Wenatchee Valley Medical Center Established on July 21, 2013, Confluence Health is an affiliation between...
Click here to add this to my saved trials
1 Medical Center Blvd
Winston-Salem, North Carolina 27103
Winston-Salem, North Carolina 27103
(336) 716-2011
Wake Forest University Comprehensive Cancer Center Our newly expanded Comprehensive Cancer Center is the region’s...
Click here to add this to my saved trials
Hickman Cancer Center at Bixby Medical Center At ProMedica Bixby Hospital, we
Click here to add this to my saved trials
Kapiolani Medical Center at Pali Momi Pali Momi Medical Center is a nonprofit hospital located...
Click here to add this to my saved trials
1 Akron General Ave
Akron, Ohio 44307
Akron, Ohio 44307
(330) 344-6000
McDowell Cancer Center at Akron General Medical Center Learning that you or someone you love...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
McFarland Clinic, PC It has been over 65 years since the founders of McFarland Clinic...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
AnMedical Health Cancer Center Cancer is the general term for a group of more than...
Click here to add this to my saved trials
Saint Joseph Mercy Cancer Center Saint Joseph Mercy Health System is one of Michigan's most...
Click here to add this to my saved trials
5301 East Huron River Drive
Ann Arbor, Michigan 48106
Ann Arbor, Michigan 48106
1.877.590.5995
CCOP - Michigan Cancer Research Consortium The Community Clinical Oncology Program (CCOP) is a comprehensive...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Randolph Hospital Since 1932, Randolph Hospital has been fortunate to employ dedicated and loyal personnel...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
5665 Peachtree Dunwoody Rd NE
Atlanta, Georgia 30342
Atlanta, Georgia 30342
(678) 843-7001
Saint Joseph's Hospital of Atlanta Founded by the Sisters of Mercy in 1880, Saint Joseph
Click here to add this to my saved trials
Click here to add this to my saved trials
Piedmont Hospital For more than a century, Piedmont Healthcare has been a recognized leader in...
Click here to add this to my saved trials
1120 15th Street, BAA-5407
Augusta, Georgia 30912
Augusta, Georgia 30912
(706) 721-2505
MBCCOP - Medical College of Georgia Cancer Center The Georgia Regents University (GRU) is located...
Click here to add this to my saved trials
Aurora Presbyterian Hospital At The Medical Center of Aurora and Centennial Medical Plaza, we treat...
Click here to add this to my saved trials
13001 E. 17th Pl.
Aurora, Colorado 80045
Aurora, Colorado 80045
303-724-5000
University of Colorado Cancer Center - Anschutz Cancer Pavilion The University of Colorado Denver |...
Click here to add this to my saved trials
Rush-Copley Cancer Care Center Rush-Copley is proud to be the leading provider of health services...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials