Evaluation of Novel Biomarkers From Acutely Ill Patients at Risk for Acute Kidney Injury

Inclusion Criteria:

Males and females 21 years of age or older;

Subjects enrolled (first sample collection) from ED or Floor admitted to the ICU within 24
hours of enrollment; Subjects enrolled from ICU admitted to the ICU within the 24 hours
prior to enrollment; Expected to remain in the ICU for at least 48 hours after enrollment;
Use of indwelling urinary catheter as standard care expected for at least 48 hours after
enrollment; At least one of the following acute conditions within 24 hours prior to
enrollment:

(Respiratory SOFA score of ≥ 2 (PaO2/FiO2 <300)and/or Cardiovascular SOFA score of ≥ 1
(MAP < 70 mm Hg and/or any vasopressor required).

Patient (or authorized representative) able and willing to provide written informed
consent for study participation.

Exclusion Criteria:

Special populations including women with known pregnancy, prisoners or institutionalized
individuals;Previous renal transplantation;Known acutely worsening renal function prior to
enrollment (e.g., any category of RIFLE criteria. Already receiving dialysis (either acute
or chronic) or in imminent need of dialysis at the time of enrollment; Known infection
with human immunodeficiency virus (HIV) or active hepatitis (acute or chronic);Patient
meets any of the following:Active bleeding with an anticipated need for > 4 units
PRBC;Hemoglobin < 7 g/dL;Any other condition that in the physician's opinion would
contraindicate drawing serial blood samples for clinical study purposes.