Effects of Continuous Positive Airway Pressure (CPAP)Treatment on Glucose Control
| Status: | Recruiting |
|---|---|
| Conditions: | Insomnia Sleep Studies, Pulmonary, Diabetes |
| Therapuetic Areas: | Endocrinology, Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/7/2015 |
| Start Date: | September 2009 |
Effects of Continuous Positive Airway Pressure (CPAP) Treatment on Glucose Control in Patients With Type 2 Diabetes
The overall goal of the proposed protocol is to rigorously test the hypothesis that CPAP
treatment has beneficial effects on glycemic control in patients with both type 2 diabetes
(T2DM) and obstructive sleep apnea (OSA). If our hypothesis were to be proven, this would
imply that CPAP treatment of OSA in patients with T2DM is an essential component of their
glycemic control. The proposed work is thus expected to provide additional preventive and
therapeutic approaches in the management of millions of patients with T2DM.
treatment has beneficial effects on glycemic control in patients with both type 2 diabetes
(T2DM) and obstructive sleep apnea (OSA). If our hypothesis were to be proven, this would
imply that CPAP treatment of OSA in patients with T2DM is an essential component of their
glycemic control. The proposed work is thus expected to provide additional preventive and
therapeutic approaches in the management of millions of patients with T2DM.
Inclusion Criteria:
- Male and female subjects with type 2 diabetes on a stable medication regimen (no
change in diabetic medications in the previous 3 months), including insulin, will be
eligible.
Exclusion Criteria:
- Subjects on an insulin pump will be excluded.
- Subjects with unstable cardiopulmonary disease, painful neuropathy, significant
psychiatric illness, cognitive impairment and pregnancy will be excluded.
- Shift workers
- Subjects having traveled across >2 time zones less than one month prior to the study
- Diagnosis of a sleep disorder other than OSA by screening polysomnography
- Previous treatment with positive airway pressure or supplemental oxygen
- Requirement of supplemental oxygen or bi-level positive airway pressure for OSA
treatment during titration
- Claustrophobia or other conditions of CPAP intolerance, and presence of active
infection.
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