Study of Blood and Tissue Samples From Patients With Aggressive Non-Hodgkin B-Cell Lymphoma or Hodgkin Lymphoma
| Status: | Completed |
|---|---|
| Conditions: | Lymphoma |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/27/2013 |
| Start Date: | August 2009 |
| End Date: | December 2013 |
| Contact: | Nina Wagner-Johnston, MD |
| Phone: | 314-362-1000 |
Evaluation of Serum Free Light Chains and Clonal Ig DNA in Plasma From Patients With Aggressive B-Cell Lymphomas
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory
may help doctors learn more about changes that occur in DNA and identify biomarkers related
to cancer.
PURPOSE: This research study is looking at blood and tissue samples from patients with
aggressive non-Hodgkin B-cell lymphoma or Hodgkin lymphoma.
OBJECTIVES:
Primary
- To estimate the proportion of patients with diffuse large B-cell/immunoblastic and
Burkitt histologies with elevated serum free light chains (FLC).
- To estimate the proportion of patients with Hodgkin lymphoma with clonal immunoglobulin
(Ig) DNA detection in the plasma.
Secondary
- To estimate the agreement between the detection of a monoclonal Ig DNA spike in plasma
and the detection of a monoclonal DNA spike in tumor tissue.
- To estimate the agreement between the fragment length of a spike in tumor tissue and
the fragment length of the spike in plasma.
- To estimate the detection rate of elevated FLC in each histology, including diffuse
large B-cell/immunoblastic and Burkitt lymphoma.
- To estimate the detection rate of clonal Ig DNA in each histology, including diffuse
large B-cell/immunoblastic, Burkitt lymphoma, and Hodgkin lymphoma.
- To analyze clinical and pathologic correlates of detection by the serum/plasma tests:
disease subtype, stage of disease, disease bulk, lactate dehydrogenase, and Ki-67
index.
- To estimate the detection rate of clonotypic B-cells in peripheral blood mononuclear
cells from patients with Hodgkin lymphoma.
OUTLINE: This is a multicenter study.
Blood and tissue samples collected at the time of diagnosis are analyzed for serum free
light chain and clonal immunoglobulin (Ig) DNA rearrangements and circulating clonotypic
B-cells via PCR.
PROJECTED ACCRUAL: A total of 50 patients (25 with diffuse large B-cell/immunoblastic
histologies, 15 with Burkitt lymphoma, and 10 with Hodgkin lymphoma) will be accrued for
this study.
DISEASE CHARACTERISTICS:
- Diagnosis of an untreated aggressive B-cell lymphoma, including:
- Diffuse large B cell/immunoblastic lymphoma
- Burkitt lymphoma
- Hodgkin lymphoma
- Serological documentation of HIV infection by any of the FDA-approved tests
- Available diagnostic material from fresh frozen tissue or formalin-fixed paraffin
embedded tissue OR willing to undergo a repeat biopsy (fine needle aspiration is
acceptable)
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
We found this trial at
19
sites
Montefiore Medical Center As the academic medical center and University Hospital for Albert Einstein College...
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Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins The name Johns Hopkins has become synonymous...
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University of Miami A private research university with more than 15,000 students from around the...
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Memorial Sloan-Kettering Cancer Center Memorial Sloan-Kettering Cancer Center — the world's oldest and largest private...
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660 S Euclid Ave #8100
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5196
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis The Alvin J. Siteman Cancer Center...
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1600 Divisadero Street
San Francisco, California 94115
San Francisco, California 94115
888.689.8273
UCSF Helen Diller Family Comprehensive Cancer Center UCSF’s long tradition of excellence in cancer research...
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72 East Concord St.
Boston, Massachusetts 02118
Boston, Massachusetts 02118
617-638-4173
Boston University Cancer Research Center
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Baylor University Medical Center - Houston Baylor University Medical Center in Dallas began in 1903...
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3855 Health Sciences Dr,
La Jolla, California 92093
La Jolla, California 92093
(858) 822-6100
UC San Diego Moores Cancer Center Established in 1978, UC San Diego Moores Cancer Center...
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1441 Eastlake Ave
Los Angeles, California 90033
Los Angeles, California 90033
(323) 865-3000
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
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Morgantown, West Virginia 26506
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Philadelphia, Pennsylvania 19106
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Sacramento, California 95814
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St. Louis, Missouri 63110
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