Randomized, Controlled Study Evaluating CERE-110 in Subjects With Mild to Moderate Alzheimer's Disease
| Status: | Completed |
|---|---|
| Conditions: | Alzheimer Disease |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/18/2012 |
| Start Date: | September 2009 |
| End Date: | December 2014 |
| Contact: | Sarah Walter, M.P.H. |
| Email: | swalter@ucsd.edu |
| Phone: | 858-622-5863 |
A Double-Blind, Placebo-Controlled (Sham Surgery), Randomized, Multicenter Study Evaluating CERE-110 Gene Delivery in Subjects With Mild to Moderate Alzheimer's Disease
The purpose of this study is to evaluate the potential benefits of CERE-110 in the treatment
of Alzheimer's disease. CERE-110 is an experimental drug that is designed to help nerve
cells in the brain function better. CERE-110 uses a virus to transfer a gene that makes
Nerve Growth Factor (NGF), a protein that may make nerve cells in the brain healthier and
protect them from dying. The virus used in CERE-110 does not cause disease in people.
CERE-110 has been carefully studied in laboratory animals and is in the early stages of
being tested in people.
Fifty patients with mild to moderate Alzheimer's disease will participate in this study.
Half of the study subjects will have CERE-110 injected into the brain during a surgical
procedure, while the other half will undergo a "placebo" surgery where no medication will be
injected. All study participants will be followed for at least two years after surgery.
Inclusion Criteria:
- Diagnosis of mild to moderate Alzheimer's disease
- Approved medications for Alzheimer's disease may be taken if the dose has been stable
for 3 months
- A study partner who can attend all study visits
- Good general health
- Medically able to undergo neurosurgery
Exclusion Criteria:
- Significant neurological disease other than Alzheimer's disease
- Significant depression or other psychiatric disorder
- Unstable medical conditions
We found this trial at
11
sites
Click here to add this to my saved trials
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
Click here to add this to my saved trials
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
Click here to add this to my saved trials
Duke University Younger than most other prestigious U.S. research universities, Duke University consistently ranks among...
Click here to add this to my saved trials
University of California at Los Angeles The University of California, Los Angeles (UCLA) is an...
Click here to add this to my saved trials
Mount Sinai School of Medicine Icahn School of Medicine at Mount Sinai is proud to...
Click here to add this to my saved trials
University of Utah Research is a major component in the life of the U benefiting...
Click here to add this to my saved trials
171 Ashley Avenue
Charleston, South Carolina 29425
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
Click here to add this to my saved trials
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
Click here to add this to my saved trials
Click here to add this to my saved trials
Georgetown University Georgetown University is one of the world's leading academic and research institutions, offering...
Click here to add this to my saved trials