Vaginal Cleansing Before Cesarean Delivery to Reduce Infection



Status:Recruiting
Conditions:Infectious Disease
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:Any
Updated:5/12/2018
Start Date:August 2015
End Date:December 2019
Contact:Antonina I Frolova, MD
Email:frolovaa@wudosis.wustl.edu
Phone:314-362-7300

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Vaginal Cleansing Before Cesarean Delivery to Reduce Infection: A Randomized Trial

The purpose of this study is to test the hypothesis that vaginal cleansing with
povidone-iodine solution immediately prior to cesarean delivery reduces postcesarean
infectious morbidity.

Cesarean delivery is the most common surgical procedure performed on women in the US; nearly
1.3 million are performed each year. Postoperative infectious morbidity is the most common
complication of cesarean delivery. Post-cesarean infectious morbidity is often the result of
indigenous vaginal flora that ascend into the uterus at the time of surgery. Thus, reducing
vaginal microbial load may reduce post-cesarean infection. However, results from studies
assessing the role of vaginal cleansing prior to cesarean have been mixed.

The investigators will perform a randomized controlled clinical trial to test the hypothesis
that vaginal cleansing with povidone-iodine solution immediately prior to cesarean delivery
reduces postcesarean infectious morbidity.

Inclusion Criteria:

- Women undergoing cesarean delivery after labor at Barnes-Jewish Hospital.

Exclusion Criteria:

- Inability to obtain consent

- known or suspected allergy to iodine or shellfish

- women with active herpes simplex virus infection
We found this trial at
1
site
Saint Louis, Missouri 63110
Principal Investigator: Lorene A Temming, MD
Phone: 314-362-7300
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mi
from
Saint Louis, MO
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