A Proof-of-Concept Study of RO6867461 in Participants With Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD)



Status:Completed
Conditions:Cardiology, Ocular
Therapuetic Areas:Cardiology / Vascular Diseases, Ophthalmology
Healthy:No
Age Range:50 - Any
Updated:9/29/2018
Start Date:August 11, 2015
End Date:September 26, 2017

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A Multiple-Center, Multiple-Dose and Regimen, Randomized, Active Comparator Controlled, Double-Masked, Parallel Group, 36 Week Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO6867461 Administered Intravitreally in Patients With Choroidal Neovascularization Secondary to Age-Related Macular Degeneration

This multiple-center, multiple-dose and regimen, randomized, double-masked active
comparator-controlled, double-masked, five parallel group, 36-week study will evaluate the
efficacy, safety, tolerability, and pharmacokinetics of RO6867461 in participants with CNV
secondary to AMD.


Inclusion Criteria:

- Treatment-naive with CNV secondary to AMD, with subfoveal CNV or juxtafoveal CNV with
a subfoveal component related to the CNV activity by FFA or SD-OCT

- Active CNV

Exclusion Criteria:

- CNV due to causes other than AMD

- Subretinal hemorrhage, fibrosis, or atrophy involving either the fovea or more than
50% of the total lesion area

- Cataract surgery within 3 months of baseline, or any other previous intraocular
surgery

- Major illness or surgery within 1 month prior to Screening

- Glycosylated hemoglobin (HbA1c) above 7.5%

- Uncontrolled blood pressure
We found this trial at
59
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5441 Health Center Drive
Abilene, Texas 79606
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Albuquerque, New Mexico 87109
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21 Medical Park Drive
Asheville, North Carolina 28803
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Augusta, Georgia 30909
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Austin, Texas 78705
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Austin, Texas 78705
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Bakersfield, California 93309
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Baltimore, Maryland
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Beverly Hills, California 90211
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6035 Fairview Road
Charlotte, North Carolina 28210
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1300 Jefferson Park Avenue
Charlottesville, Virginia 22903
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1606 Gunbarrel Road
Chattanooga, Tennessee 37421
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Chevy Chase, Maryland 20815
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2770 North Union Boulevard
Colorado Springs, Colorado 80909
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Columbus, OH
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Dallas, Texas 75231
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7760 France Avenue South
Edina, Minnesota 55435
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Encino, California 91436
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Eugene, Oregon 97401
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Florence, South Carolina 29501
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Fort Myers, Florida 33907
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Fort Myers, Florida 33912
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Fullerton, California 92835
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1432 Kimbrough Road
Germantown, Tennessee 38138
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Golden, Colorado 80401
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Hamden, Connecticut 06518
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200 Motor Parkway
Hauppauge, New York 11788
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2424 Century Place Southeast
Hickory, North Carolina 28603
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Houston, Texas 77030
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10300 North Illinois Street
Indianapolis, Indiana 46290
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360 Merrick Road
Lynbrook, New York 11563
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Marietta, Georgia 30060
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1518 East Barnett Road
Medford, Oregon 97504
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502 East New Haven Avenue
Melbourne, Florida 32901
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Nashville, Tennessee 37203
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Oceanside, California 92056
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44 Lake Beauty Drive
Orlando, Florida 32806
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Paducah, Kentucky 42001
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Palm Beach Gardens, Florida 33410
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Philadelphia, Pennsylvania 19107
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Phoenix, Arizona 85014
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Phoenix, Arizona 85020
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Portland, Oregon 97210
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Poway, California 92064
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160 Sawgrass Drive
Rochester, New York 14620
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4344 Central Avenue North
Saint Petersburg, Florida 33711
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Salt Lake City, Utah
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Santa Ana, California 92705
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SLingerlands, New York 12159
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Spokane, Washington 99204
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2439 Care Drive
Tallahassee, Florida 32308
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628 Cedar Lane
Teaneck, New Jersey 07666
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Towson, Maryland 21204
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Tucson, Arizona 85704
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Ventura, California 93003
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Walnut Creek, California 94598
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Whittier, California 90603
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Willow Park, Texas 76087
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Worcester, Massachusetts 01605
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