Randomized Study Comparing Local Tumor Control After Post-Operative Single-Fraction or Hypofractionated Stereotactic Radiosurgery in the Treatment of Spinal Metastases



Status:Completed
Healthy:No
Age Range:18 - Any
Updated:2/21/2019
Start Date:December 16, 2014
End Date:July 26, 2018

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Phase III Multicenter Randomized Study Comparing Local Tumor Control After Post-Operative Single-Fraction or Hypofractionated Stereotactic Radiosurgery in the Treatment of Spinal Metastases

The purpose of this study is to find out whether giving one higher dose of radiation is as
good at treating the tumor in the patient's spine after surgery as giving three lower doses
of radiation.


Inclusion Criteria:

- Histologically diagnosed metastatic cancer (Diagnosis made or confirmed at MSKCC for
MSKCC participants. Institutional pathologic determination accepted from participating
multicenter sites.)

- Age ≥18 years

- Life expectancy ≥3 months

- ECOG ≤ 3

- Spinal surgery carried out with the goal of spinal cord decompression and spinal
stabilization within 8 weeks

- Post-operative CT myelogram or MRI perfusion with evidence of separation of tumor and
the spinal cord It should be noted that patients with multiple lesions will be
eligible as long as there are no overlapping fields of radiation, including at various
time frames.

Exclusion Criteria:

- Primary spine tumor

- Age < 18

- Pregnancy

- Lack of adequate (≥ 2 mm) separation between the spinal cord and the tumor on
post-operative CT myelogram or MRI perfusion

- Radiosensitizing chemotherapy (taxol, taxotere, cisplatin, gemcitabine,
5-fluorouracil) given within one week of radiation treatment
We found this trial at
4
sites
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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Baltimore, Maryland 21287
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1275 York Ave
New York, New York 10021
(212) 639-2000
Principal Investigator: Ilya Laufer, MD
Phone: 212-639-2368
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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New York, NY
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300 Pasteur Dr
Stanford, California 94305
(650) 723-4000
Stanford Univ Med Ctr The Medical Center is uniquely advantaged by its location on the...
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Stanford, CA
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