Randomized Study Comparing Local Tumor Control After Post-Operative Single-Fraction or Hypofractionated Stereotactic Radiosurgery in the Treatment of Spinal Metastases
Status: | Completed |
---|---|
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 2/21/2019 |
Start Date: | December 16, 2014 |
End Date: | July 26, 2018 |
Phase III Multicenter Randomized Study Comparing Local Tumor Control After Post-Operative Single-Fraction or Hypofractionated Stereotactic Radiosurgery in the Treatment of Spinal Metastases
The purpose of this study is to find out whether giving one higher dose of radiation is as
good at treating the tumor in the patient's spine after surgery as giving three lower doses
of radiation.
good at treating the tumor in the patient's spine after surgery as giving three lower doses
of radiation.
Inclusion Criteria:
- Histologically diagnosed metastatic cancer (Diagnosis made or confirmed at MSKCC for
MSKCC participants. Institutional pathologic determination accepted from participating
multicenter sites.)
- Age ≥18 years
- Life expectancy ≥3 months
- ECOG ≤ 3
- Spinal surgery carried out with the goal of spinal cord decompression and spinal
stabilization within 8 weeks
- Post-operative CT myelogram or MRI perfusion with evidence of separation of tumor and
the spinal cord It should be noted that patients with multiple lesions will be
eligible as long as there are no overlapping fields of radiation, including at various
time frames.
Exclusion Criteria:
- Primary spine tumor
- Age < 18
- Pregnancy
- Lack of adequate (≥ 2 mm) separation between the spinal cord and the tumor on
post-operative CT myelogram or MRI perfusion
- Radiosensitizing chemotherapy (taxol, taxotere, cisplatin, gemcitabine,
5-fluorouracil) given within one week of radiation treatment
We found this trial at
4
sites
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1275 York Ave
New York, New York 10021
New York, New York 10021
(212) 639-2000
Principal Investigator: Ilya Laufer, MD
Phone: 212-639-2368
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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Stanford Univ Med Ctr The Medical Center is uniquely advantaged by its location on the...
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