A Study Investigating the Safety and Efficacy of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration



Status:Terminated
Conditions:Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:50 - Any
Updated:3/16/2019
Start Date:October 6, 2014
End Date:January 23, 2018

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A Phase III, Multicenter, Randomized, Double-Masked, Sham-Controlled Study to Assess the Efficacy and Safety of Lampalizumab Administered Intravitreally to Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration

This study is a Phase III, double-masked, multicenter, randomized, sham injection-controlled
study evaluating the efficacy and safety of lampalizumab administered by intravitreal
injections in participants with geographic atrophy (GA) secondary to age-related macular
degeneration (AMD).


Inclusion Criteria:

- Participants aged greater than or equal to (>/=) 50 years

- Well demarcated area(s) of Geographic Atrophy (GA) secondary to Age-Related Macular
Degeneration (AMD) with no evidence of prior or active choroidal neovascularization
(CNV) in both eyes

Exclusion Criteria:

Ocular Exclusion Criteria (Study Eye):

- History of vitrectomy surgery, submacular surgery, or other surgical intervention for
AMD

- Previous laser photocoagulation for CNV, diabetic macular edema, retinal vein
occlusion, and proliferative diabetic retinopathy

- Previous intravitreal drug delivery (e.g., intravitreal corticosteroid injection,
anti-angiogenic drugs, anti-complement agents, or device implantation)

Ocular Exclusion Criteria (Both Eyes):

- GA in either eye due to causes other than AMD

- Previous treatment with eculizumab, lampalizumab, and/or fenretinide
We found this trial at
68
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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4202 E Fowler Ave
Tampa, Florida 33620
(813) 974-2011
University of South Florida The University of South Florida is a high-impact, global research university...
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5441 Health Center Drive
Abilene, Texas 79606
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Ann Arbor, Michigan 48105
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21 Medical Park Drive
Asheville, North Carolina 28803
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Aurora, Colorado 80045
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Baltimore, Maryland 21209
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Baltimore, Maryland
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Bellevue, Washington 98004
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243 Charles Street
Boston, Massachusetts 02114
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1832 Avenida Córdoba
Capital Federal, C1120AAN
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735 Johnnie Dodds Boulevard
Charleston, South Carolina 29464
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6035 Fairview Road
Charlotte, North Carolina 28210
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1300 Jefferson Park Avenue
Charlottesville, Virginia 22903
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1606 Gunbarrel Road
Chattanooga, Tennessee 37421
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8 Ranoldo Terrace
Cherry Hill, New Jersey 08034
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1815 Clarkson Road
Chesterfield, Missouri 63017
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Chevy Chase, Maryland 20815
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Cincinnati, Ohio 45242
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2770 North Union Boulevard
Colorado Springs, Colorado 80909
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Dallas, Texas 75231
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Detroit, Michigan 48201
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2351 Erwin Road
Durham, North Carolina 27710
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7760 France Avenue South
Edina, Minnesota 55435
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Florence, South Carolina 29501
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Fort Lauderdale, Florida 33334
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Fort Myers, Florida 33907
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Fullerton, California 92835
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1432 Kimbrough Road
Germantown, Tennessee 38138
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Golden, Colorado 80401
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Hamden, Connecticut 06518
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Houston, Texas 77030
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La Jolla, California 92093
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9551 U.S. 78
Ladson, South Carolina 29456
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Los Angeles, California
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2485 Hospital Drive
Mountain View, California 94040
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3880 Tamiami Trail North
Naples, Florida 34103
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New York, New York 10021
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460 Park Avenue
New York, New York 10022
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1500 Tilton Road
Northfield, New Jersey 08225
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Omaha, Nebraska 68105
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Paducah, Kentucky 42001
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2452 Watson Court
Palo Alto, California 94303
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Philadelphia, Pennsylvania 19107
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Phoenix, Arizona 85020
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420 East North Avenue
Pittsburgh, Pennsylvania 15212
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Portland, Oregon 97210
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3303 Southwest Bond Avenue
Portland, Oregon 97239
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Poway, California 92064
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Rapid City, South Dakota 57701
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Reno, Nevada 89502
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160 Sawgrass Drive
Rochester, New York 14620
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Sacramento, California 95817
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Sacramento, California 95819
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4344 Central Avenue North
Saint Petersburg, Florida 33711
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Santa Barbara, California 93103
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2439 Care Drive
Tallahassee, Florida 32308
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628 Cedar Lane
Teaneck, New Jersey 07666
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Temple, Texas 76508
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The Woodlands, Texas 77384
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Wichita, Kansas 67214
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