A Trial Comparing the Safety and Efficacy of Insulin Degludec and Insulin Glargine, Both With Insulin Aspart as Mealtime Insulin in Subjects With Type 1 Diabetes



Status:Completed
Conditions:Diabetes, Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - Any
Updated:1/3/2019
Start Date:January 5, 2014
End Date:January 11, 2016

Use our guide to learn which trials are right for you!

A Randomised, Double Blind, Cross-over Trial Comparing the Safety and Efficacy of Insulin Degludec and Insulin Glargine, Both With Insulin Aspart as Mealtime Insulin in Subjects With Type 1 Diabetes (SWITCH 1)

This trial is conducted in Europe and the United States of America (USA). The aim of the
trial is to compare the safety and efficacy of insulin degludec (IDeg) and insulin glargine
(IGlar), both with insulin aspart (IAsp) as mealtime insulin in subjects with type 1
diabetes.


Inclusion Criteria: - Subjects fulfilling at least one of the below criteria: a)
Experienced at least one severe hypo episode within the last year (according to the ADA
(American Diabetes Association) definition, April 2013) b) Moderate chronic renal failure,
defined as glomerular filtration rate 30 - 59 mL/min/1.73 m^2 per CKD-Epi (chronic kidney
disease epidemiology collaboration) c) Hypoglycaemic symptom unawareness d) Diabetes
mellitus duration for more than 15 years e) Recent episode of hypoglycaemia (defined by
symptoms of hypoglycaemia and/or episode with low glucose measurement (below or equal to 70
mg/dL [below or equal to 3.9 mmol/L])) within the last 12 weeks prior to Visit 1
(screening) - Male or female, age at least 18 years at the time of signing informed consent
- Type 1 diabetes mellitus (diagnosed clinically) for at least 52 weeks prior to Visit 1 -
Current treatment with a basal-bolus regimen consisting of neutral protamine Hagedorn (NPH)
insulin OD (once daily) / BID (twice daily) or insulin detemir (IDet) OD / BID plus 2-4
daily injections of any rapid acting meal time insulin or CSII (with rapid acting insulin)
for at least 26 weeks prior to Visit 1 - HbA1c (glycosylated haemoglobin) below or equal to
10% by central laboratory analysis - BMI (body mass index) below or equal to 45 kg/m^2
Exclusion Criteria: - Treatment with IGlar or IDeg within the last 26 weeks prior to Visit
1 (short term use [less than or equal to 2 weeks] is allowed, but not within 4 weeks prior
to screening) - Use of any other anti-diabetic agent than those stated in the inclusion
criteria within the last 26 weeks prior to Visit 1
We found this trial at
85
sites
Albany, New York 12208
?
mi
from
Albany, NY
Click here to add this to my saved trials
Amarillo, Texas 79106
?
mi
from
Amarillo, TX
Click here to add this to my saved trials
Anderson, Indiana 46011
?
mi
from
Anderson, IN
Click here to add this to my saved trials
Arlington Heights, Illinois 60004
?
mi
from
Arlington Heights, IL
Click here to add this to my saved trials
Asheville, North Carolina 28801
?
mi
from
Asheville, NC
Click here to add this to my saved trials
Austin, Texas 78731
?
mi
from
Austin, TX
Click here to add this to my saved trials
?
mi
from
Bialystok,
Click here to add this to my saved trials
Billings, Montana 59101
?
mi
from
Billings, MT
Click here to add this to my saved trials
Birmingham, Alabama 35215
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
Carrollton, Texas 75007
?
mi
from
Carrollton, TX
Click here to add this to my saved trials
Chattanooga, Tennessee 37404
?
mi
from
Chattanooga, TN
Click here to add this to my saved trials
Chesapeake, Virginia 23321
?
mi
from
Chesapeake, VA
Click here to add this to my saved trials
Chicago, Illinois 60612
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Concord, California 94520
?
mi
from
Concord, CA
Click here to add this to my saved trials
Cooper City, Florida 33024
?
mi
from
Cooper City, FL
Click here to add this to my saved trials
Council Bluffs, Iowa 51501
?
mi
from
Council Bluffs, IA
Click here to add this to my saved trials
Crystal Lake, Illinois 60012
?
mi
from
Crystal Lake, IL
Click here to add this to my saved trials
Dallas, Texas 75231
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Denver, Colorado 80220
?
mi
from
Denver, CO
Click here to add this to my saved trials
El Paso, Texas 79912
?
mi
from
El Paso, TX
Click here to add this to my saved trials
Escondido, California 92025
?
mi
from
Escondido, CA
Click here to add this to my saved trials
Federal Way, Washington 98003
?
mi
from
Federal Way, WA
Click here to add this to my saved trials
Fleming Island, Florida 32003
?
mi
from
Fleming Island, FL
Click here to add this to my saved trials
Fort Lauderdale, Florida 33316
?
mi
from
Fort Lauderdale, FL
Click here to add this to my saved trials
Fresno, California 93702
?
mi
from
Fresno, CA
Click here to add this to my saved trials
Goodyear, Arizona 85395
?
mi
from
Goodyear, AZ
Click here to add this to my saved trials
Greenville, North Carolina 27834
?
mi
from
Greenville, NC
Click here to add this to my saved trials
Hamilton, New Jersey 08619
?
mi
from
Hamilton, NJ
Click here to add this to my saved trials
Harrison, New York 10528
?
mi
from
Harrison, NY
Click here to add this to my saved trials
Hazelwood, Missouri 63042
?
mi
from
Hazelwood, MO
Click here to add this to my saved trials
Henderson, Nevada 89052
?
mi
from
Henderson, NV
Click here to add this to my saved trials
Hialeah, Florida 33012
?
mi
from
Hialeah, FL
Click here to add this to my saved trials
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Idaho Falls, Idaho 83404
?
mi
from
Idaho Falls, ID
Click here to add this to my saved trials
Indianapolis, Indiana 46260
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
Jacksonville, Florida 32207
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
Jefferson City, Missouri 65109
?
mi
from
Jefferson City, MO
Click here to add this to my saved trials
800 Scudders Mill Road
Jenkintown, Pennsylvania 19046
?
mi
from
Jenkintown, PA
Click here to add this to my saved trials
Kansas City, Missouri 64106
?
mi
from
Kansas City, MO
Click here to add this to my saved trials
?
mi
from
Katy, TX
Click here to add this to my saved trials
Kingsport, Tennessee 37660
?
mi
from
Kingsport, TN
Click here to add this to my saved trials
La Jolla, California 92037
?
mi
from
La Jolla, CA
Click here to add this to my saved trials
Las Vegas, Nevada 89128
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
Lawrenceville, Georgia 30046
?
mi
from
Lawrenceville, GA
Click here to add this to my saved trials
Lenexa, Kansas 66219
?
mi
from
Lenexa, KS
Click here to add this to my saved trials
Lexington, Kentucky 40503
?
mi
from
Lexington, KY
Click here to add this to my saved trials
Livonia, Michigan 48152
?
mi
from
Livonia, MI
Click here to add this to my saved trials
Long Beach, California 90807
?
mi
from
Long Beach, CA
Click here to add this to my saved trials
Mesquite, Texas 75149
?
mi
from
Mesquite, TX
Click here to add this to my saved trials
Miami, Florida 33136
?
mi
from
Miami, FL
Click here to add this to my saved trials
Miami Springs, Florida 33166
?
mi
from
Miami Springs, FL
Click here to add this to my saved trials
Milwaukee, Wisconsin 53209
?
mi
from
Milwaukee, WI
Click here to add this to my saved trials
Mineola, New York 11501
?
mi
from
Mineola, NY
Click here to add this to my saved trials
Morehead City, North Carolina 28557
?
mi
from
Morehead City, NC
Click here to add this to my saved trials
Nashua, New Hampshire 03063
?
mi
from
Nashua, NH
Click here to add this to my saved trials
New Port Richey, Florida 34652
?
mi
from
New Port Richey, FL
Click here to add this to my saved trials
Norfolk, Virginia 23510
?
mi
from
Norfolk, VA
Click here to add this to my saved trials
Oklahoma City, Oklahoma 73112
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
Omaha, Nebraska 68114
?
mi
from
Omaha, NE
Click here to add this to my saved trials
Pembroke Pines, Florida 33026
?
mi
from
Pembroke Pines, FL
Click here to add this to my saved trials
Philadelphia, Pennsylvania 19104
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Pittsburgh, Pennsylvania 15224
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Port Charlotte, Florida 33952
?
mi
from
Port Charlotte, FL
Click here to add this to my saved trials
Port Orange, Florida 32127
?
mi
from
Port Orange, FL
Click here to add this to my saved trials
Raleigh, North Carolina 27610
?
mi
from
Raleigh, NC
Click here to add this to my saved trials
Rancho Cucamonga, California 91730
?
mi
from
Rancho Cucamonga, CA
Click here to add this to my saved trials
Renton, Washington 98057
?
mi
from
Renton, WA
Click here to add this to my saved trials
Richardson, Texas 75080
?
mi
from
Richardson, TX
Click here to add this to my saved trials
Richland, Washington 99352
?
mi
from
Richland, WA
Click here to add this to my saved trials
Salt Lake City, Utah 84132
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
San Antonio, Texas 78224
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
San Mateo, California 94401
?
mi
from
San Mateo, CA
Click here to add this to my saved trials
San Ramon, California 94583
?
mi
from
San Ramon, CA
Click here to add this to my saved trials
Santa Monica, California 90404
?
mi
from
Santa Monica, CA
Click here to add this to my saved trials
Schertz, Texas 78154
?
mi
from
Schertz, TX
Click here to add this to my saved trials
Skokie, Illinois 60077
?
mi
from
Skokie, IL
Click here to add this to my saved trials
Spokane, Washington 99202
?
mi
from
Spokane, WA
Click here to add this to my saved trials
Sugar Land, Texas 77479
?
mi
from
Sugar Land, TX
Click here to add this to my saved trials
Syracuse, New York 13210
?
mi
from
Syracuse, NY
Click here to add this to my saved trials
?
mi
from
Toledo, OH
Click here to add this to my saved trials
Topeka, Kansas 66606
?
mi
from
Topeka, KS
Click here to add this to my saved trials
Upland, California 91786
?
mi
from
Upland, CA
Click here to add this to my saved trials
Ventura, California 93003
?
mi
from
Ventura, CA
Click here to add this to my saved trials
Walla Walla, Washington 99362
?
mi
from
Walla Walla, WA
Click here to add this to my saved trials
West Des Moines, Iowa 50265
?
mi
from
West Des Moines, IA
Click here to add this to my saved trials