A Phase 1 Study of IMGN289 in Adult Patients With EGFR-positive Solid Tumors
Status: | Terminated |
---|---|
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 4/21/2016 |
Start Date: | October 2013 |
End Date: | April 2015 |
A Phase 1, Multi-center, Open-label Study of IMGN289 Administered Intravenously in Adult Patients With EGFR-positive Solid Tumors
This is a Phase 1, first-in-human study to determine the recommended dose of IMGN289 in
adult patients with advanced EGFR-positive tumors.
adult patients with advanced EGFR-positive tumors.
Inclusion Criteria:
- 18 years old at time of consent
- Diagnosed with a solid tumor that has progressed despite standard therapy or for
which no standard effective or curative options exist or are suitable
- EGFR-positive tumor expression
- Adequate blood and organ function
- Must agree to use contraception while on study and for 12 weeks after the last dose
of IMGN289 as applicable
- Must be willing and able to sign informed consent and follow the study schedule and
other protocol requirements
Exclusion Criteria:
- Other anti-cancer treatment during the study
- Symptomatic brain metastases
- Other clinically significant disease as defined by the protocol
- Chronic skin condition that requires prescribed oral or intravenous treatment
- History of severe rash that required discontinuation of prior EGFR targeted therapy
- Receiving therapeutic doses of warfarin or heparin for anti-coagulation
- Known diagnosis of HIV or active viral hepatitis
- Women who are pregnant or breast feeding
We found this trial at
4
sites
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
Click here to add this to my saved trials
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins The name Johns Hopkins has become synonymous...
Click here to add this to my saved trials
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
Click here to add this to my saved trials
Click here to add this to my saved trials