IL-15 Super Agonist ALT-803 to Treat Relapse Of Hematologic Malignancy After Allogeneic SCT



Status:Active, not recruiting
Conditions:Blood Cancer, Lymphoma, Hematology
Therapuetic Areas:Hematology, Oncology
Healthy:No
Age Range:18 - Any
Updated:9/28/2018
Start Date:November 11, 2013
End Date:June 2020

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IL-15 Super Agonist ALT-803 to Treat Relapse Of Hematologic Malignancy After Allogeneic Stem Cell Transplantation

This is a multi-center, phase I/II clinical trial for patients who have relapsed more than 60
day after allogeneic transplant for a hematologic malignancy. The study consists of two
phases. The dose finding phase is a modified version of a phase I trial and the extended
phase is a modified version of a phase II trial.

The primary objective of the dose finding phase is to determine the maximum tolerated,
minimum efficacious dose (MTD/MED) of a interleukin-15 (IL-15) super agonist complex
(ALT-803) when given once weekly for 4 weeks in the outpatient setting. The study will follow
a standard 3+3 design of dose escalation for toxicity with an added feature of stopping early
if efficacy is confirmed. There are six dose levels of ALT-803 for to determine the MTD/MED:
1, 3, 6, 10, 20, and 30 mcg/kg.

Once the MTD/MED for ALT-803 is determined, this cohort will be used in the extended phase.
The primary goal of this extended phase is to study the potential efficacy of ALT-803 in this
patient population. Efficacy will be measured using rates of remission induction. An optimal
Simon's two-stage design will be used in this phase. Stage 1 will enroll 14 patients
(including the 6 patients treated at the MTD/MED during the dose finding phase). If 3 or more
of these 14 patients respond to ALT-803, the trial will move to stage 2 and enroll an
additional 23 patients. If 2 or fewer respond, the study will terminate enrollment early.


Inclusion Criteria:

- Relapse after previous allogeneic stem cell transplant for one of the following
hematologic malignancies (acute myelogenous leukemia, acute lymphoblastic
leukemia,myelodysplastic syndromes, lymphoma, myeloma, Chronic lymphocytic Leukemia,
chronic myelogenous leukemia):

- For non-CML, relapse will be defined based on disease specific morphologic
criteria from a bone marrow biopsy and aspirate or recurrence of disease specific
cytogenetics. For disease specific definition of relapse, see appendix III.
Relapse can be determined morphologically. Equivocal results for relapse should
result in a repeated test after an appropriate time interval (suggested 1 month)
to determine eligibility.

- For CML, relapse will be defined as any cytogenetic evidence of a Philadelphia
chromosome or persistence of BCR/ABL rearrangements by molecular testing on at
least two measurements over a 6 month interval. If cytogenetics are normal and
there is PCR evidence of a BCR/ABL fusion, patients will be eligible if they have
evidence of a quantitative increase in CML measured either by quantitative PCR or
by fluorescent in situ hybridization (FISH).

For Chronic Phase CML patients only:

- must have failed (no response in 3 months or incomplete response at 6 months) or
refused treatment with a tyrosine-kinase inhibitor (TKI)

- must have failed (defined as incomplete response or relapse) or refused DLI

- Relapse must have occurred ≥ 60 days after transplant

- Prior DLI is allowed, however not within the 30 days before the 1st dose of ALT-803

- Minimum donor chimerism of 10%

- ≥ 18 years of age

- Karnofsky performance status ≥ 70% (appendix II)

- Adequate organ function within 14 days (30 days for cardiac and pulmonary) of
enrollment defined as:

- Creatinine: ≤ 2.0 mg/dL

- Hepatic: SGOT/SGPT < 5 x upper limit of institutional normal (ULN)

- Thyroid Function: Thyroid Stimulating Hormone (TSH) within institutional normal
range - patients with thyroid disease are eligible if euthyroid on suppressive or
replacement therapy

- Pulmonary: PFTs > 50% of predicted

- Cardiac: LVEF by ECHO or MUGA > 40%

- Ability to be off prednisone and other immunosuppressive drugs for at least 30 day
before first dose of study drug

- Patient agrees to stay within a reasonable distance (i.e. 30 miles) of the study site
for the duration of the study treatment and for a minimum of 48 hours after the last
dose and has a dedicated care giver as is standard practice for BMT outpatient care

- Women of child bearing potential and men with partners of child bearing potential must
agree to use effective contraception during therapy and for 4 months after completion
of therapy

- Voluntary written consent

Exclusion Criteria:

- Post-transplant lymphoproliferative diseases (often referred to as EBV-associated
lymphomas)

- Known active CNS leukemia or lymphoma - patients with previously treated CNS disease
is permitted if neurologically stable with no ongoing or anticipated need for steroid
therapy are eligible

- Ongoing active acute or chronic GVHD requiring immunosuppressive therapy or signs of
aGVHD or cGVHD requiring treatment

- Pregnant or lactating - Women of child bearing potential must have a negative
pregnancy test within 14 days of study treatment start

- Class II or greater New York Heart Association Functional Classification criteria
(appendix II) or serious cardiac arrhythmias likely to increase the risk of cardiac
complications of cytokine therapy (e.g. ventricular tachycardia, frequent ventricular
ectopy, or supraventricular tachyarrhythmia requiring chronic therapy

- Marked baseline prolongation of QT/QTc interval (e.g. demonstration of a QTc interval
greater than 500 milliseconds)

- New progressive pulmonary infiltrates on screening chest x-ray or chest CT scan for
which evaluation with bronchoscopy is not feasible. Infiltrates attributed to
infection must be stable/improving (with associated clinical improvement) after 1 week
of appropriate therapy (4 weeks for presumed or documented fungal infections).

- Active bacterial, fungal, or viral infections - all prior infections must have
resolved following optimal therapy

- Positive hepatitis C serology or active hepatitis B infection because of the risk of
hepatic inflammation and the possible confounding of drug toxicity assessment -
chronic asymptomatic viral hepatitis is allowed

- HIV positive because the effect of IL-15 viral loads, HIV immunity, and infectivity of
proliferating T cells is unknown

- History of severe asthma, presently on chronic medications (a history of mild asthma
not requiring therapy is eligible)
We found this trial at
3
sites
425 E River Pkwy # 754
Minneapolis, Minnesota 55455
612-624-2620
Principal Investigator: Jeffrey S. Miller, MD
Phone: 612-626-0169
Masonic Cancer Center at University of Minnesota The Masonic Cancer Center was founded in 1991....
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3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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Saint Louis, Missouri 63110
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Saint Louis, MO
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