Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures



Status:Completed
Healthy:No
Age Range:18 - 50
Updated:4/25/2018
Start Date:October 2012
End Date:August 15, 2017

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Cortisol is a stress hormone that can be measured in saliva. This has provided a convenient
way to evaluate the biological impact of day-to-day stressors that people encounter as they
go about their lives, since saliva is so easy to collect. However, the biological meaning of
saliva cortisol measures has never been carefully examined. The goal of this study is to
collect saliva from a large group of people as they go about their every-day lives, to
measure their cortisol levels, and then study them in the laboratory where Investigators can
learn more about how their stress response system (which produces cortisol) is really
functioning. Investigators can then determine much more precisely what saliva cortisol levels
really mean in terms of stress system biology. This will allow investigators to obtain much
more useful information from the next decade of research on naturalistic stress and its
biological impact using saliva cortisol measures, helping investigators to understand how
stress undermines health and how to combat this effect.


Inclusion Criteria:

- Medically healthy volunteers, ages 18 to 50 years

Exclusion Criteria:

- Pregnancy

- Irregular menses, medications or drugs that effect HPA axis

- Most psychiatric disorders

- Medical problems that effect HPA axis or increase risks involved in participation
We found this trial at
1
site
1500 E Medical Center Dr
Ann Arbor, Michigan 48109
(734) 936-4000
Principal Investigator: James L Abelson, MD
Phone: 734-764-5348
University of Michigan Health System The University of Michigan is home to one of the...
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Ann Arbor, MI
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