Open Label Study of Long Term Evaluation Against LDL-C Trial



Status:Completed
Conditions:High Cholesterol
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - 75
Updated:11/4/2018
Start Date:October 7, 2011
End Date:June 20, 2018

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A Multicenter, Controlled, Open-label Extension (OLE) Study to Assess the Long-term Safety and Efficacy of AMG 145 (Evolocumab)

The primary clinical hypothesis is that long-term exposure of evolocumab (AMG 145) will be
safe and well tolerated in subjects with hypercholesterolemia.


Inclusion Criteria:

- Complete a qualifying evolocumab (AMG 145) parent study protocol

Exclusion Criteria:

- Experienced a treatment-related serious adverse event that led to IP discontinuation
in the parent study

- Have an unstable medical condition, in the judgment of the investigator

- Known sensitivity to any of the products to be administered during dosing

- Currently enrolled in another investigational device or drug study (excluding
evolocumab (AMG 145) parent study), or less than 30 days since ending another
investigational device or drug study(s),or receiving other investigational agent(s)
We found this trial at
70
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Akron, OH
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Anaheim, CA
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Bristol, TN
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Brockton, MA
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Brooklyn Center, Minnesota 55430
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Cadiz, OH
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Camperdown,
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Colorado Springs, Colorado 80910
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Cortlandt Manor, New York 10567
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Dayton, OH
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DeLand, FL
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Duncansville, Pennsylvania 16635
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Duncansville, PA
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Endwell, NY
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Fargo, ND
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Great Falls, MT
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Mission Viejo, California 92691
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Mount Pleasant, South Carolina 29464
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Newport Beach, California 92660
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Thousand Oaks, California 91360
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