Study of Amiloride on Vascular Phenotypes in Young Adults With Prehypertension
Status: | Unknown status |
---|---|
Conditions: | High Blood Pressure (Hypertension) |
Therapuetic Areas: | Cardiology / Vascular Diseases |
Healthy: | No |
Age Range: | 18 - 35 |
Updated: | 10/14/2017 |
Start Date: | September 2010 |
Contact: | Samip J Parikh, MBBS, MPH |
Email: | sparikh@georgiahealth.edu |
Phone: | 7067211764 |
Primary Specific Aim: To test the hypothesis that amiloride will improve vascular health of
young adults with prehypertension.
young adults with prehypertension.
Inclusion Criteria:
- Prehypertensive: Having systolic BP between 120 to 139 mmHg and/or diastolic BP
between 80 to 89 mmHg during screening visit. BP will be measured manually tree times
at 10 minutes interval after subjects sit quietly for at least 5 minutes in a chair.
The average of last two BP measurements will be taken into consideration.
- Male or female of Caucasian or African-American origin.
- No history of any major past and current medical illness (such as diabetes, renal
disease, liver disease etc.)
- Not taking any medication that affects blood pressure.
Exclusion Criteria:
- HbA1C > 7.0 % during screening visit.
- Serum potassium > 5.5 mEq/L during screening and/or any testing visit due to risk of
developing hyperkalemia.
- Serum creatinine > 1.5 mg/100 ml and/or creatinine clearance < 50 ml/min* (Glomerular
Filtration Rate Estimate by Abbreviated MDRD Study Equation)35 during screening and/or
any testing visit due to risk of developing renal dysfunction.
- Female having positive pregnancy test during screening and/or any testing visit.
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