Study of Amiloride on Vascular Phenotypes in Young Adults With Prehypertension



Status:Unknown status
Conditions:High Blood Pressure (Hypertension)
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - 35
Updated:10/14/2017
Start Date:September 2010
Contact:Samip J Parikh, MBBS, MPH
Email:sparikh@georgiahealth.edu
Phone:7067211764

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Primary Specific Aim: To test the hypothesis that amiloride will improve vascular health of
young adults with prehypertension.


Inclusion Criteria:

- Prehypertensive: Having systolic BP between 120 to 139 mmHg and/or diastolic BP
between 80 to 89 mmHg during screening visit. BP will be measured manually tree times
at 10 minutes interval after subjects sit quietly for at least 5 minutes in a chair.
The average of last two BP measurements will be taken into consideration.

- Male or female of Caucasian or African-American origin.

- No history of any major past and current medical illness (such as diabetes, renal
disease, liver disease etc.)

- Not taking any medication that affects blood pressure.

Exclusion Criteria:

- HbA1C > 7.0 % during screening visit.

- Serum potassium > 5.5 mEq/L during screening and/or any testing visit due to risk of
developing hyperkalemia.

- Serum creatinine > 1.5 mg/100 ml and/or creatinine clearance < 50 ml/min* (Glomerular
Filtration Rate Estimate by Abbreviated MDRD Study Equation)35 during screening and/or
any testing visit due to risk of developing renal dysfunction.

- Female having positive pregnancy test during screening and/or any testing visit.
We found this trial at
1
site
Augusta, Georgia 30912
Principal Investigator: Yanbin Dong, MD, PhD
?
mi
from
Augusta, GA
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