A Study Investigating the Efficacy and Safety of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration



Status:Completed
Conditions:Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:50 - Any
Updated:10/25/2018
Start Date:September 18, 2014
End Date:January 29, 2018

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A Phase III, Multicenter, Randomized, Double-Masked, Sham-Controlled Study to Assess the Efficacy and Safety of Lampalizumab Administered Intravitreally to Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration

This study is a Phase III, double-masked, multicenter, randomized, sham injection-controlled
study evaluating the efficacy and safety of lampalizumab administered by intravitreal
injections in participants with geographic atrophy (GA) secondary to age-related macular
degeneration (AMD).


Inclusion Criteria:

- Well demarcated area(s) of GA secondary to AMD with no evidence of prior or active
choroidal neovascularization (CNV) in both eyes

Exclusion Criteria:

Ocular Exclusion Criteria: Study Eye

- History of vitrectomy surgery, submacular surgery, or other surgical intervention for
AMD

- Previous laser photocoagulation for CNV, diabetic macular edema, retinal vein
occlusion, and proliferative diabetic retinopathy

- Previous intravitreal drug delivery (intravitreal corticosteroid injection,
anti-angiogenic drugs, anti-complement agents, or device implantation) Ocular
Exclusion Criteria: Both Eyes

- GA in either eye due to causes other than AMD

- Previous treatment with eculizumab, lampalizumab and/or fenretinide
We found this trial at
77
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98-1079 Moanalua Road
'Aiea, Hawaii 96701
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5441 Health Center Drive
Abilene, Texas 79606
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Arlington, Texas 76012
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21 Medical Park Drive
Asheville, North Carolina 28803
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Augusta, Georgia 30909
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Austin, Texas 78705
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Austin, Texas 78705
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Bakersfield, California 93309
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3401 Enterprise Place
Beachwood, Ohio 44122
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Beverly Hills, California 90211
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1720 7th Avenue South
Birmingham, Alabama 35233
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Bloomfield, New Jersey 07003
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800 Washington Street
Boston, Massachusetts 02111
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Boston, Massachusetts 02114
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1717 Woolbright Road
Boynton Beach, Florida 33426
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725 Uruguay
Buenos Aires, C1015ABO
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Chicago, IL
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5323 Harry Hines Boulevard
Dallas, Texas 75390
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Fort Myers, Florida 33912
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Grand Rapids, Michigan 49525
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200 Motor Parkway
Hauppauge, New York 11788
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10300 North Illinois Street
Indianapolis, Indiana 46290
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1116 West Ganson Street
Jackson, Michigan 49202
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9551 U.S. 78
Ladson, South Carolina 29456
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Las Vegas, Nevada
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4 Princess Road
Lawrenceville, New Jersey 08648
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16 Hayden Avenue
Lexington, Kentucky 02421
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Lexington, Kentucky 40509
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Lincoln, Nebraska 38506
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Los Angeles, California
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360 Merrick Road
Lynbrook, New York 11563
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Madison, Wisconsin 53792
(608) 263-2400
University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
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Marietta, Georgia 30060
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McAllen, Texas 78503
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502 East New Haven Avenue
Melbourne, Florida 32901
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Monroeville, Pennsylvania 15146
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Morgantown, West Virginia 26506
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Nashville, Tennessee 37203
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Nashville, Tennessee 37212
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Oakland, California 94609
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Orchard Park, New York 14127
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Palm Beach Gardens, Florida 33410
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Palm Beach Gardens, Florida 33418
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36949 Cook Street
Palm Desert, California 92211
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Pensacola, Florida 32503
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Phoenix, Arizona 85014
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Plantation, Florida 33324
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Portland, Maine
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8411 North Run Medical Drive
Richmond, Virginia 23226
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Royal Oak, Michigan 48073
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4344 Central Avenue North
Saint Petersburg, Florida 33711
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1445 Bush Street
San Francisco, California 94107
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400 Parnassus Avenue
San Francisco, California 94143
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Shawnee Mission, Kansas 66204
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9800 Levin Road Northwest
Silverdale, Washington 98383
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Southfield, Michigan 48034
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Spokane, Washington 99204
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3107 East Genesee Street
Syracuse, New York 13224
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2439 Care Drive
Tallahassee, Florida 32308
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Tampa, Florida 33609
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Warrenton, Virginia 20186
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West Des Moines, Iowa 50266
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West Mifflin, Pennsylvania 15122
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Willow Park, Texas 76087
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1 Medical Center Blvd
Winston-Salem, North Carolina 27157
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Worcester, Massachusetts 01605
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