A Study of Emibetuzumab in Non Small Cell Lung Cancer (NSCLC) Participants



Status:Completed
Conditions:Lung Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:6/27/2018
Start Date:August 2013
End Date:March 2016

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A Randomized, Open-Label Phase 2 Study Evaluating LY2875358 Plus Erlotinib and LY2875358 Monotherapy in MET Diagnostic Positive NSCLC Patients With Acquired Resistance to Erlotinib

The primary purpose of this study is to evaluate the efficacy of the study drug known as
LY2875358, administered alone or in combination with a second drug named Erlotinib, in
participants affected by a defined type of lung cancer (MET biomarker diagnostic positive
Non-Small-Cell Lung Cancer) that experienced a disease progression during the most recent
treatment with Erlotinib.


Inclusion Criteria:

- Diagnosis of metastatic Stage IV NSCLC

- At least 1 measurable extra-central nervous system (CNS) lesion

- Documented radiographic progression while on continuous treatment with erlotinib
monotherapy

- Objective clinical benefit from erlotinib treatment as defined by either documented
partial or complete response or stable disease ≥6 months or, if most recent erlotinib
treatment has been initiated based on documented epidermal growth factor receptor
mutation (EGFRmt) status, at least 12 weeks stable disease

- Determined to be MET diagnostic positive (+)

- Availability of a tumor sample post-erlotinib progression

- Eastern Cooperative Oncology Group (ECOG) performance status ≤2

- Have adequate organ function

Exclusion Criteria:

- Are currently enrolled in, or discontinued within the last 30 days from, a clinical
trial involving an investigational product or non-approved use of a drug or device

- Have previously been treated with LY2875358 or any other MET-targeting experimental
therapeutic

- Have a serious concomitant systemic disorder or significant cardiac disease

- Have interstitial pneumonia or interstitial fibrosis of the lung or have pleural
effusion, pericardial fluids or ascites, requiring drainage every other week or more
frequently

- Have a history of another malignancy except for basal or squamous cell skin cancer
and/or in situ carcinoma of the cervix, or other solid tumors treated curatively and
without evidence of recurrence for at least 3 years prior to the study

- Have major surgery less than 2 weeks prior initiation of study treatment therapy

- Pregnant or lactating women

- Have symptomatic CNS metastasis
We found this trial at
33
sites
201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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1045 North 30th Street
Billings, Montana 59101
406-255-8470
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Billings, MT
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Birmingham, AL
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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Boston, MA
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1000 Blythe Blvd
Charlotte, North Carolina 28203
(704) 355-2000
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Charlotte, NC
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3840 Broadway
Fort Myers, Florida 33901
(239) 275-6400
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Fort Myers, FL
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116th St and Broadway
New York, New York 10027
(212) 854-1754
Columbia University In 1897, the university moved from Forty-ninth Street and Madison Avenue, where it...
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825 Eastlake Ave E
Seattle, Washington 98109
(206) 288-7222
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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Aalst,
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Athens, Georgia 30607
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Aurora, CO
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Chattanooga, Tennessee 37404
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5053 Wooster Rd
Cincinnati, Ohio 45226
(513) 751-2273
Oncology Hematology Care Our more than 60 physicians and advanced practice providers throughout neighborhood offices...
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Detroit, Michigan 48201
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Iowa City, Iowa 52242
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Kirkland, Washington 98034
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9500 Gilman Dr
La Jolla, California 92093
(858) 534-2230
The University of California, San Diego UC San Diego is an academic powerhouse and economic...
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La Jolla, CA
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1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
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100 N Humphreys Blvd
Memphis, Tennessee 38120
(901) 683-0055
The West Clinic, PC Hello and welcome to our office. Although it is our pleasure...
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250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
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Philadelphia, Pennsylvania 19111
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Portland, Oregon 97239
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Portland, OR
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Rochester, Minnesota 55905
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Sacramento, CA
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Saint Louis, Missouri 63110
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Saint Petersburg, Florida 33705
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Santa Monica, California 90404
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Seattle, Washington 98124
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314 Martin Luther King Junior Way
Tacoma, Washington 98405
(253) 403-5200
Multicare Health System MultiCare is a not-for-profit health care organization with more than 10,000 employees...
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Tampa, Florida 33612
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Washington, District of Columbia 20007
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Westwood, Kansas 66205
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