A Phase 3 Study of Ganetespib in Combination With Docetaxel Versus Docetaxel Alone in Patients With Advanced NSCLC



Status:Terminated
Conditions:Lung Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:March 2013
End Date:December 2015

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A Randomized, Phase 3 Study of Ganetespib in Combination With Docetaxel Versus Docetaxel Alone in Patients With Advanced Non-Small-Cell Lung Adenocarcinoma

The purpose of this study is to determine whether combining ganetespib (STA-9090) with
docetaxel is more effective than docetaxel alone in the treatment of patients with advanced
non-small cell lung cancer.

Preliminary signals of clinical activity of ganetespib as a single agent have been observed
in patients with advanced NSCLC. A Phase 2b/3 Study (9090-08) was initiated to evaluate the
safety and activity of ganetespib in combination with docetaxel vs. docetaxel alone in
NSCLC. Study 9090-08 is ongoing. Results from an interim analysis show that the combination
has been well tolerated and an encouraging improvement in efficacy, including overall
survival(OS) has been observed.

Inclusion Criteria:

- Advanced Stage IIIB or IV NSCLC

- Eastern Oncology Cooperative Group (ECOG) Performance Status 0 or 1

- Prior therapy defined as 1 prior systemic therapy for advanced disease

- Documented disease progression during or following most first line therapy for
advanced disease

- Adequate hematologic, hepatic, renal function

Exclusion Criteria:

- EGFR mutations

- ALK translocations

- Predominantly squamous, adenosquamous or unclear histologic type

- Active or untreated CNS metastases

- Active malignancies other than NSCLC within the last 5 years with the exception of
adequately treated cone-biopsied in situ carcinoma of the cervix uteri or basal or
squamous cell carcinoma of the skin

- Serious cardiac illness or medical conditions

- Pregnant or lactating women

- Uncontrolled intercurrent illness
We found this trial at
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Anaheim, California 92801
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Chapel Hill, North Carolina 27599
(919) 962-2211
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303 North Clyde Morris Boulevard
Daytona Beach, Florida 32114
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11143 Parkview Plaza Dr # 100
Fort Wayne, Indiana 46845
(260) 484-8830
Fort Wayne Medical Oncology and Hematology Fort Wayne Medical Oncology and Hematology provides state-of-the-art cancer...
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Albuquerque, New Mexico 87109
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Annapolis, Maryland 21401
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Arlington, Texas 76014
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Arlington, Texas 76012
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Bakersfield, California 93309
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Beaumont, Texas 77702
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450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Bridgeton, Missouri 63044
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Charlotte, North Carolina 28204
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Chattanooga, Tennessee 37404
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Chattanooga, Tennessee 37403
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5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
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Dallas, Texas 75246
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Denver, Colorado 80218
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2799 W Grand Blvd
Detroit, Michigan 48202
(313) 916-2600
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Duluth, Minnesota 55805
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East Setauket, New York 11733
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Everett, Washington 98201
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Flagstaff, Arizona 86002
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Green Bay, Wisconsin 54301
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Green Bay, Wisconsin 54303
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Hagerstown, Maryland 21742
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Hollywood, Florida 33021
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Houston, Texas 77090
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1915 White Ave.
Knoxville, Tennessee 37916
(865) 541-1678
Thompson Cancer Survival Center The Thompson Cancer Survival Center Downtown facility has pioneered many advances...
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Krems, Niederösterreich 3500
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3855 Health Sciences Dr,
La Jolla, California 92093
(858) 822-6100
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Lake Success, New York 11042
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1215 E Michigan Ave
Lansing, Michigan 48912
(517) 364-2890
Sparrow Regional Cancer Center Sparrow has grown to become the region's largest health system, and...
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Loma Linda, California 92354
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Los Angeles, California 90095
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Los Angeles, California 90073
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Marietta, Georgia 30060
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Marietta, Georgia 30060
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Morgantown, West Virginia 26506
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Norwich, Connecticut 06360
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200 Lothrop St
Pittsburgh, Pennsylvania 15213
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Portland, Oregon 97227
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Prescott Valley, Arizona 86314
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353 Fairmont Blvd
Rapid City, South Dakota 57701
(605) 719-1000
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Redondo Beach, California 90277
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Reno, Nevada 89502
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Rockford, Illinois 61108
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Saint Louis Park, Minnesota 55426
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100 NE Loop 410; Suite 600
San Antonio, Texas 78216
210-424-1600
Cancer Care Centers of South Texas At Cancer Care Centers of South Texas, we are...
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100 NE Loop 410; Suite 600
San Antonio, Texas 78216
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100 NE Loop 410; Suite 600
San Antonio, Texas 78216
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Sayre, Pennsylvania 18840
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Sherman, Texas 75090
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South Pasadena, California 91030
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Spokane Valley, Washington 99216
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Tacoma, Washington 98405
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Tucson, Arizona 85712
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12697 E 51st Street South
Tulsa, Oklahoma 74146
918-505-3200
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Watertown, South Dakota 57201
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West Palm Beach, Florida 33401
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Winston-Salem, North Carolina 27103
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