Assessment of Ability of Breath Hold for Left-sided Breast Cancer Radiation Therapy to Reduce Side Effects to Heart



Status:Active, not recruiting
Conditions:Breast Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 99
Updated:4/21/2016
Start Date:March 2013
End Date:February 2016

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Prospective Pilot Study of Assessment of Breath Hold as a Means to Mitigate the Risk of Radiation-associated Reductions in Regional Cardiac Perfusion in Patients With Left-sided Breast Cancer

The purpose of this research study is to demonstrate that Deep Inspiration Breath Hold
(DIBH), the technique used at the University of North Carolina (UNC) for left-side breast
cancer radiation therapy, can reduce side effects to the heart.

The primary objective of this study is to estimate the rate of radiation-associated regional
myocardial perfusion defects in patients 6 months after breast/chestwall radiation with DIBH
for left-sided breast cancer. Cardiac perfusion will be assessed using SPECT cardiac
perfusion scans pre- and 6 months post-radiation.

Inclusion Criteria:

- signed an Institutional Review Board (IRB)-approved informed consent document for
protocol

- age >= 18 years

- histologically confirmed left-sided breast cancer scheduled to undergo curative
intent radiation treatment post lumpectomy or mastectomy

- stage 0-III left-sided breast cancer (including DCIS)

- SPECT score of 0 at baseline

- radiation oncologist agrees target volume coverage will not be compromised via use of
the DIBH technique along with conformal field shaping

Exclusion Criteria:

- active cardiac disease, defined as a history of angina, arrhythmias, myocardial
infarction, congestive heart failure, or any other cardiac condition, which in the
opinion of the treating physician would make this protocol unreasonably hazardous for
the patient

- symptomatic pulmonary disease currently requiring regular medication including but
not restricted to bronchodilators

- concurrent chemotherapy

- prior receipt of mediastinal radiation therapy

- pregnant or lactating women

- inability to understand and follow breathing instructions for the DIBH procedure
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