Pazopanib Hydrochloride in Treating Patients With Progressive Carcinoid Tumors



Status:Active, not recruiting
Conditions:Skin Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Brain Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/13/2019
Start Date:June 21, 2013

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Prospective Randomized Phase II Trial of Pazopanib (NSC # 737754) Versus Placebo in Patients With Progressive Carcinoid Tumors

This randomized phase II trial studies how well pazopanib hydrochloride works in treating
patients with carcinoid tumors that are growing, spreading, or getting worse. Pazopanib
hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for
cell growth.

PRIMARY OBJECTIVES:

I. For patients with progressive carcinoid tumors, progression-free survival (PFS defined by
central review according to Response Evaluation Criteria in Solid Tumors [RECIST] 1.1) will
be compared between patients randomized to treatment with pazopanib (pazopanib hydrochloride)
versus placebo.

SECONDARY OBJECTIVES:

I. Overall survival (OS) will be compared between treatment arms. II. Objective response
rate, duration of response, and time to treatment failure will be compared between treatment
arms.

III. Progression free survival (PFS) as assessed by central radiology review and local
radiology review will be compared overall and within treatment arms.

IV. Safety and tolerability of treatment with pazopanib/placebo will be evaluated within each
treatment arm.

V. PFS and other indicators of efficacy will be estimated in patients who crossover to
pazopanib from placebo.

VI. To determine the turn-around time for timely adjudicated central review. VII. To
characterize the nature of discordance between local and central radiology review in
assessment of progression.

VIII. To characterize the type and rate of progression in carcinoid (at study entry,
on-study, and at progression).

IX. To develop new methods for modeling carcinoid growth and detecting treatment effects, and
to perform simulations that advance new clinical trial designs to apply to future trials of
carcinoid therapeutics.

X. To assess for differences in quality of life (QOL)-related domains between the two
treatment groups (pazopanib versus placebo).

XI. To determine if the more brief measures of QOL-related domains provide comparable
information to that which is provided by the longer assessments (European Organization for
Research and Treatment of Cancer [EORTC], neuroendocrine tumors [NET]21).

XII. To provide validation data for the EORTC NET21 module in terms of responsiveness over
time and differences across arms.

XIII. To determine whether components of the plasma angiome panel that have been shown to be
predictive previously (interleukin-6 [IL-6] and vascular endothelial growth factor [VEGF]-D)
are predictive of a therapeutic advantage for pazopanib treatment in baseline samples from
the patients treated on A021202.

XIV. To determine whether other components of the plasma angiome panel tested (not IL-6 and
VEGF-D) are predictive of a therapeutic advantage for pazopanib treatment in baseline samples
from the patients treated on A021202.

XV. To evaluate the changes in the plasma angiome markers after treatment with or without
pazopanib over time.

EXPLORATORY OBJECTIVES:

I. PFS at 6 months will be estimated within each treatment arm. II. Biochemical response (for
chromogranin A, defined as a decrease of 50% or more in chromogranin A levels from baseline
and for 5-hydroxyindoleacetic acid [5-HIAA], defined as a decrease of 50% or more in urinary
5-HIAA levels from baseline) will be compared between treatment arms among patients with
elevated baseline levels of chromogranin A (CGA) and 5-HIAA.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive pazopanib hydrochloride orally (PO) once daily (QD) on days 1-28.
Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive placebo PO QD on days 1-28. Courses repeat every 28 days in the
absence of disease progression or unacceptable toxicity. At the time of progressive disease,
patients may cross-over to Arm I.

After completion of study treatment, patients are followed up every 3-6 months for 5 years.

Inclusion Criteria:

- Low- or intermediate-grade neuroendocrine carcinoma, including the following subtypes:
carcinoid tumor, low- to intermediate-grade or well- to moderately-differentiated
neuroendocrine carcinoma or tumor, atypical carcinoid tumor; documentation from a
primary tumor or metastatic site is sufficient; patients with poorly differentiated
neuroendocrine carcinoma, high-grade neuroendocrine carcinoma, adenocarcinoid tumor,
or goblet cell carcinoid tumor are not eligible

- Locally unresectable or metastatic carcinoid tumors

- Patients must have histologic documentation or clinical evidence of a carcinoid tumor
of primary site (including foregut, midgut, hindgut or other non-pancreatic site);
tumors of unknown primary site are eligible provided the treating physician does not
suspect medullary thyroid cancer, pancreatic neuroendocrine tumor, paraganglioma, or
pheochromocytoma; unknown primary tumors will be classified as small bowel tumors for
the purpose of stratification; functional (associated with a clinical syndrome) or
nonfunctional tumors are allowed; target lesions must have shown disease progression
if therapy included peptide receptor radiotherapy (PRRT) and PRRT must be completed at
least 8 weeks prior to registration

- Radiological evidence for progressive disease (measurable or non-measurable) within 12
months prior to registration; patients who have received anti-tumor therapy during the
past 12 months (including octreotide analogs) must have had radiological documentation
of progression of disease while on or after receiving therapy

- No known endobronchial lesions and/or lesions infiltrating major pulmonary vessels
that increase the risk of pulmonary hemorrhage; patients with lesions infiltrating
major pulmonary vessels (contiguous tumor and vessels) are excluded; however, the
presence of a tumor that is touching, but not infiltrating (abutting) the vessels is
acceptable (computed tomography [CT] with contrast is strongly recommended to evaluate
such lesions); patients with large protruding endobronchial lesions in the main or
lobar bronchi are excluded; however, endobronchial lesions in the segmented bronchi
are allowed

- Patients must have measurable disease per RECIST 1.1 by computed tomography (CT) scan
or magnetic resonance imaging (MRI); lesions must be accurately measured in at least
one dimension (longest diameter to be recorded) as >= 1 cm with CT or MRI (or >= 1.5
cm for lymph nodes); index lesions for the purpose of RECIST 1.1 measurements will not
be selected from within the radiation therapy treatment field; however, if there is
evidence of disease progression within the radiation treatment field, measurement of
the progressing lesions will be documented

- No prior treatment with an inhibitor of vascular endothelial growth factor (VEGF) or
vascular endothelial growth factor receptor (VEGFR)

- Prior treatment (somatostatin analogs excepted) must be completed at least 2 weeks
prior to registration; in addition, prior treatment (somatostatin analogs excepted)
must be completed at least 4 weeks prior to initiation of study drug;
treatment-related toxicities must have improved to =< grade 1 prior to registration,
with the exception of alopecia

- Concurrent use of somatostatin analogs (SSTa) is allowed, provided that the patient is
on a stable dose for at least two months and progressive disease on somatostatin
analog has been documented; progression on octreotide is required for patients with
tumors arising in the midgut

- Prior treatment with embolization (including bland embolization, chemoembolization,
and selective internal radiation therapy) or ablative therapies is allowed if
measurable disease remains outside of the treated area or there is documented disease
progression in a treated site; there is no limit on the prior number of procedures;
prior liver-directed or other ablative treatment must be completed at least 8 weeks
prior to registration; index lesions for the purpose of RECIST 1.1 measurements will
not be selected from within the radiation therapy treatment field; however, if there
is evidence of disease progression within the radiation treatment field, measurement
of the progressing lesions will be documented

- Patients should have completed any major surgery >= 4 weeks prior to registration and
must have completed any minor surgery >= 2 weeks prior to registration; patients must
have fully recovered from the procedure

- The following are examples of procedures considered to be minor: port placement,
laparoscopy, thoracoscopy, bronchoscopy, mediastinoscopy, skin biopsies,
incisional biopsies, imaging-guided biopsy for diagnostic purposes, and dental
extraction procedures

- Insertion of a vascular access device, thoracentesis, paracentesis, and
endoscopic ultrasonographic procedures are not considered to be major or minor
surgeries

- No concurrent condition resulting in immune compromise, including chronic treatment
with corticosteroids or other immunosuppressive agents

- No clinical evidence of central nervous system (CNS) metastases (including
carcinomatous meningitis) at baseline, with the exception of those patients who have
previously-treated CNS metastases (surgery +/- radiotherapy, radiosurgery, or gamma
knife) and who meet both of the following criteria: a) are asymptomatic and b) had no
requirement for steroids or enzyme-inducing anticonvulsants within 6 months prior to
registration

- No history of abdominal fistula, gastrointestinal perforation, or intra-abdominal
abscess within 28 days prior to registration

- No clinically significant gastrointestinal abnormalities that may increase the risk
for gastrointestinal bleeding within 28 days prior to registration including, but not
limited to:

- Active peptic ulcer

- Known endoluminal metastatic lesion(s) with history of bleeding

- Inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease), or other
gastrointestinal conditions with increased risk of perforation

- No history of serious (i.e., requiring active medical therapy with medication or
medical device under the supervision of a physician) non-healing wound, ulcer, trauma,
or bone fracture within 28 days prior to study entry

- Patients with a history of hypertension must have blood pressure that is adequately
controlled on antihypertensives; (< 140/90 mm Hg)

- No symptomatic congestive heart failure (New York Heart Association class II, III, or
IV) within 6 months prior to registration

- No arterial thrombotic events within 6 months of registration, including transient
ischemic attack (TIA), cerebrovascular accident (CVA), peripheral arterial thrombus,
myocardial infarction (MI), or unstable angina or angina requiring surgical or medical
intervention in 6 months prior to registration; patients with clinically significant
peripheral artery disease (i.e., claudication on less than one block) are ineligible;
patients who have experienced a deep venous thrombosis or pulmonary embolus within 6
months prior to registration must be on stable therapeutic anticoagulation for at
least 6 weeks prior to enrollment of this study

- Patients on therapeutic anticoagulation with low molecular weight heparins,
fondaparinux, rivaroxaban or warfarin are eligible, provided that they are on a stable
dose of anticoagulants; patients who are currently receiving antiplatelet therapy of
prasugrel or clopidogrel or antiaggregation agents (e.g., eptifibatide, epoprostenol,
dipyridamole) or low doses of acetylsalicylic acid (up to 100 mg daily) are also
eligible

- No ongoing cardiac dysrhythmias, atrial fibrillation, or prolongation of corrected QT
(QTc) interval to > 480 msec

- No evidence of active bleeding, bleeding diathesis, or hemoptysis (>= 1/2 teaspoon of
red blood) within 8 weeks prior to registration

- No currently unstable angina and/or uncontrolled cardiac arrhythmias

- Patients with symptomatic peripheral vascular disease are ineligible

- Ejection fraction on echocardiogram (Echo) or multi gated acquisition scan (MUGA) >
50%

- Chronic concomitant treatment with strong inhibitors of cytochrome P450, family 3,
subfamily A, polypeptide 4 (CYP3A4) is not allowed on this trial; patients on strong
CYP3A4 inhibitors must discontinue the drug 14 days prior to the start of study
treatment

- Women must not be pregnant or nursing; women of child bearing potential must have a
negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent
units of human chorionic gonadotropin [HCG]) within 72 hours prior to registration;
women of child-bearing potential include any female who has experienced menarche and
who has not undergone surgical sterilization (hysterectomy, bilateral tubal ligation
or bilateral oophorectomy) or is not postmenopausal (defined as amenorrhea >= 12
consecutive months; or women on hormone replacement therapy [HRT] with documented
serum follicle stimulating hormone [FSH] level > 35 mIU/mL)

- Eastern Cooperative Oncology Group (ECOG) performance status 0-1

- Granulocytes >= 1,500/mcL

- Platelets >= 100,000/mcL

- International normalized ratio (INR) =< 1.2 X upper limit of normal (ULN); only
required for patients receiving anticoagulant therapy; patients are eligible if their
INR is stable and within the recommended range for the desired level of
anticoagulation

- QTc =< 480 msecs

- Thyroid stimulating hormone (TSH) within normal limits (WNL); medications for thyroid
dysfunction are allowed as long as TSH is normal at registration; in patients with
abnormal TSH, if the free thyroxine (free T4) and free thyroxine index (FTI) are
normal and patient is clinically euthyroid, patient is eligible

- Bilirubin =< 1.5 x ULN

- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) &
alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x
ULN; concomitant elevations in bilirubin and AST/ALT above 1.0 X ULN are NOT
permitted; also, if liver metastases are present, AST & ALT =< 5 x ULN is allowed

- Serum creatinine =< 1.5 x ULN

- Urine protein to creatinine ratio < 1, or, 24-hour urine protein < 1 g; if urine
protein to creatinine (UPC) >= 1, then a 24-hour urine protein must be assessed;
patients must have a 24-hour urine protein value < 1 g to be eligible; use of urine
dipstick for renal function assessment is not acceptable
We found this trial at
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1201 Camino de Salud Northeast
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3500 Gaston Avenue
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8700 Beverly Blvd # 8211
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4805 Northeast Glisan Street
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60 Crittenden Blvd # 70
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4502 Medical Drive
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Dayton, Ohio 45406
(937) 734-2612
Good Samaritan Hospital - Dayton Good Samaritan Hospital (GSH) is passionate about providing the most...
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Dayton, Ohio 45415
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Dearborn, Michigan 48124
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Dearborn, MI
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2300 N Edward St
Decatur, Illinois 62526
(217) 876-8121
Decatur Memorial Hospital An American flag bearing only 48 stars waved above Decatur Memorial Hospital...
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Decatur, IL
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210 West McKinley Avenue
Decatur, Illinois 62526
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561 W. Central Avenue
Delaware, Ohio 43015
(740) 615-1000
Grady Memorial Hospital As the center of healthcare in Delaware County, Grady Memorial Hospital is...
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Delaware, OH
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Delaware, Ohio 43015
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561 West Central Avenue
Delaware, Ohio 43015
(740) 615-1000
Delaware Health Center-Grady Cancer Center As the center of healthcare in Delaware County, Grady Memorial...
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Delaware, OH
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Denver, CO
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4567 E 9th Ave
Denver, Colorado 80220
(303) 320-2121
Rose Medical Center Well known as a Denver institution and a 9th Avenue landmark for...
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2525 S Downing St
Denver, Colorado 80210
(303) 778-1955
Porter Adventist Hospital Founded in 1930, Porter Adventist Hospital has provided people throughout Denver and...
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Denver, CO
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Denver, Colorado 80220
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1721 East 19th Ave., Suite #200 & #300
Denver, Colorado 80218
720-754-4800
Colorado Blood Cancer Institute When patients come to the Colorado Blood Cancer Institute, the entire...
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Denver, CO
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Denver, Colorado 80218
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