Optimizing DBS Electrode Placement and Programming



Status:Completed
Conditions:Parkinsons Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - 70
Updated:3/1/2014
Start Date:March 2013
End Date:December 2015
Contact:Eric W. Maurer, B.A.
Phone:(612)626-2770

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Optimizing DBS Electrode Placement and Programming Using a Combination of High‐Field MRI, Intraoperative Electrophysiology, and Computational Modeling.

Deep brain stimulation has become the primary surgical therapy for the treatment of motor
symptoms associated with Parkinson's disease, and for essential tremor. Although an
effective and relatively safe procedure with expanding indications, opportunities exist for
the optimization of the current procedure.

The investigators therefore propose, in a group of patients undergoing DBS surgery for the
treatment of PD or ET, to use a combination of high‐field imaging modalities, intraoperative
electrophysiology, external sensor interfaces, and computational modeling, to gather
information on the utility of using these techniques to optimize DBS electrode placement and
programming.


Inclusion Criteria:

- A diagnosis of idiopathic Parkinson's disease or essential tremor

- Ability to provide informed consent

Exclusion Criteria:

- Claustrophobia or other conditions that prevent undergoing MR imaging

- MMSE score < 23

- Significant neurological diagnosis other than PD or ET.

- Idiopathic dystonia
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Minneapolis, Minnesota 55455
(612) 625-5000
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