Pilot Study To Assess Effect of Treatment and Adherence in PD Subjects



Status:Completed
Conditions:Parkinsons Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - 80
Updated:5/5/2014
Start Date:June 2012
End Date:February 2014
Contact:Jessica Carlson
Email:jessica.carlson@duke.edu
Phone:919-668-2841

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Assessment of the Effect of Treatment Pathways, Adherence, and Treatment Efficacy in Parkinson's Disease Subjects Randomized to SPECT Imaging of the Dopamine Transporter (Ioflupane I123 Injection)

The purpose of this study is to evaluate the impact of imaging the brain as a diagnostic
tool in the management of early Parkinson's disease (PD).

The imaging drug used in this study is Ioflupane (123I) Injection, also referred to as
DaTscan. DaTscan is FDA approved.

Inclusion Criteria:

- age 18-80;

- diagnosis of idiopathic PD exhibiting at least 2 of 3 cardinal signs (bradykinesia,
rigidity and resting tremor);

- maximum duration of previous exposure to anti-parkinsonian therapy being < 8 weeks;

- ability to signed informed consent;

- willingness and ability to complete medication diary and questionnaires;

- if a female subject of child-bearing potential, the use of an effective method of
contraception.

Exclusion Criteria:

- current treatment with anti-parkinsonian medication;

- previous treatment with anti-parkinsonian medication for greater than 8 weeks;

- inability to complete questionnaires;

- unwillingness to complete all questionnaires and medication diary;

- subjects with secondary causes of parkinsonism;

- participant has evidence of clinical significant thyroid disease, gastrointestinal,
cardiovascular, hepatic, renal, hematologic, neoplastic, endocrine, neurologic,
immunodeficiency, pulmonary, or other medical or psychiatric disorder;

- positive serum/urine pregnancy test at any time during the study period;

- the participant has a history of alcohol, narcotic, or any other drug abuse as
defined by the DSM-IV within the past 2 years;

- participation in a concurrent PD trial within 60 days.
We found this trial at
1
site
Durham, North Carolina 27705
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Durham, NC
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