Study of Tissue and Blood Samples From Patients With High-Grade Glioma



Status:Completed
Conditions:Brain Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:1/19/2019
Start Date:November 1995
End Date:January 15, 2019

Use our guide to learn which trials are right for you!

Diagnostic And Prognostic Markers In High-Grade Glioma

RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer. It may also help doctors predict how patients will respond to
treatment.

PURPOSE: This research study is looking at tissue and blood samples from patients with
high-grade glioma.

OBJECTIVES:

- To evaluate the diagnostic and prognostic relevance of various molecular, cytogenetic,
and other tumor markers in high-grade glioma in paraffin-embedded tissue collected from
patients enrolled in the Mayo Clinic or North Central Cancer Treatment Group (NCCTG)
high-grade glioma trials conducted since 1979.

- To evaluate alterations of specific chromosomes and chromosomal regions including 7, 9p,
10p, 10q, 13q, 17p, 17q, 19q, 22q, X, and Y using PCR analysis of microsatellite repeats
and FISH.

- To determine DNA ploidy by flow cytometric analysis.

- To examine various markers of cellular proliferation and cellular function including
flow cytometric determination of %S-phase, %G2M, and immunohistochemical evaluation of
PCNA, Ki-67, and p53.

- To evaluate additional markers identified by the Glioma Markers Network.

- To compare the incidence of markers in the major histologic subtypes (anaplastic
astrocytoma [AA], anaplastic oligoastrocytoma [AOA], glioblastoma multiforme [GBM]) and
to assess their correlation in the total group, as well as within each of these
subtypes.

- To compare the ploidy determinations by FISH and flow cytometry.

OUTLINE: Paraffin-embedded tissue and peripheral blood samples, previously or currently
collected from clinical trials participants at the time she/he enrolled in the trial, are
evaluated for as many markers as possible, changes in cytogenic and molecular genetic tumor
markers, frequency distributions of all tumor markers and histological and clinical variables
by polymerase chain reaction, IHC, flow cytometry, and FISH analysis.

- Patients with newly diagnosed high-grade gliomas

- Patients participating in NCCTG/Alliance or Mayo protocols

- Willing to provide mandatory blood and tissue samples for research purposes; note: 15
unstained slides may be submitted in place of a tissue block
We found this trial at
111
sites
960 W. Wooster
Bowling Green, Ohio 43402
419-352-9498
Wood County Oncology Center The Cancer Care Center at Wood County Hospital opened March 2014,...
?
mi
from
Bowling Green, OH
Click here to add this to my saved trials
3535 Olentangy River Road
Columbus, Ohio 43214
(614) 566-5000
Riverside Methodist Hospital Cancer Care Serving central Ohio since 1892, Riverside Methodist is consistently ranked...
?
mi
from
Columbus, OH
Click here to add this to my saved trials
1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
?
mi
from
Flint, MI
Click here to add this to my saved trials
19229 Mack Ave
Grosse Pointe Woods, Michigan 48236
(866) 246-4673
Van Elslander Cancer Center at St. John Hospital and Medical Center We built the Van...
?
mi
from
Grosse Pointe Woods, MI
Click here to add this to my saved trials
1 Gustave L Levy Pl # 271
New York, New York 10029
 (212) 241-6500
Mount Sinai Med Ctr Founded in 1852, The Mount Sinai Hospital is a 1,171-bed, tertiary-care...
?
mi
from
New York, NY
Click here to add this to my saved trials
777 Kimole Ln
Adrian, Michigan 49221
517-265-0900
Hickman Cancer Center at Bixby Medical Center At ProMedica Bixby Hospital, we
?
mi
from
Adrian, MI
Click here to add this to my saved trials
5301 McAuley Drive
Ann Arbor, Michigan 48197
734-712-4673
Saint Joseph Mercy Cancer Center Saint Joseph Mercy Health System is one of Michigan's most...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
5301 East Huron River Drive
Ann Arbor, Michigan 48106
1.877.590.5995
CCOP - Michigan Cancer Research Consortium The Community Clinical Oncology Program (CCOP) is a comprehensive...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
1233 34th St NW
Bemidji, Minnesota 56601
(218) 333-5000
MeritCare Bemidji Sanford Health is an integrated health system headquartered in the Dakotas and is...
?
mi
from
Bemidji, MN
Click here to add this to my saved trials
?
mi
from
Bettendorf, IA
Click here to add this to my saved trials
500 N 8th St
Bismarck, North Dakota 58501
(701) 222-6100
Bismarck Cancer Center The Bismarck Cancer Center (BCC) is a joint venture between Sanford Health...
?
mi
from
Bismarck, ND
Click here to add this to my saved trials
900 E Broadway Ave
Bismarck, North Dakota 58501
(701) 530-5550
Mid Dakota Clinic, PC We're your family clinic, with the doctors you know and trust...
?
mi
from
Bismarck, ND
Click here to add this to my saved trials
720 E Rosser Ave
Bismarck, North Dakota 58501
(701) 323-6741
Medcenter One Hospital Cancer Care Center Sanford Health is an integrated health system headquartered in...
?
mi
from
Bismarck, ND
Click here to add this to my saved trials
900 East Broadway
Bismarck, North Dakota 58501
701.530.7000
St. Alexius Medical Center Cancer Center Throughout the healing continuum we are dedicated to our...
?
mi
from
Bismarck, ND
Click here to add this to my saved trials
2200 E Washington St,
Bloomington, Illinois 61701
(309) 662-3311
St. Joseph Medical Center Located in Bloomington, Illinois, OSF St. Joseph Medical Center is a...
?
mi
from
Bloomington, IL
Click here to add this to my saved trials
1505 Eastland Drive
Bloomington, Illinois 61701
309-662-2102
Illinois CancerCare-Bloomington Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood diseases. Our...
?
mi
from
Bloomington, IL
Click here to add this to my saved trials
1055 N Curtis Rd
Boise, Idaho 83706
(208) 367-2121
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center Saint Alphonsus Health System...
?
mi
from
Boise, ID
Click here to add this to my saved trials
210 W Walnut St
Canton, Illinois 61520
309-647-5240
Illinois CancerCare - Canton Illinois CancerCare is one of the largest private oncology and hematology...
?
mi
from
Canton, IL
Click here to add this to my saved trials
210 W Walnut St
Canton, Illinois 61520
(309) 647-5240
Graham Hospital At Graham Hospital, we have a proud and rich history of serving the...
?
mi
from
Canton, IL
Click here to add this to my saved trials
1454 North County Road 2050
Carthage, Illinois 62321
(217) 357-8500
Memorial Hospital Memorial Hospital is a vital force in establishing and maintaining the well-being of...
?
mi
from
Carthage, IL
Click here to add this to my saved trials
160 S Adams St
Carthage, Illinois 62321
(217) 357-6877
Illinois CancerCare - Carthage Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
?
mi
from
Carthage, IL
Click here to add this to my saved trials
701 10th St SE
Cedar Rapids, Iowa 52403
(319) 365-4673
Mercy Regional Cancer Center at Mercy Medical Center Hall-Perrine Cancer Center is a part of...
?
mi
from
Cedar Rapids, IA
Click here to add this to my saved trials
525 10th St SE
Cedar Rapids, Iowa 52403
(319) 363-8303
Cedar Rapids Oncology Associates Oncology Associates at Mercy Medical Center in Cedar Rapids (also known...
?
mi
from
Cedar Rapids, IA
Click here to add this to my saved trials
272 Hospital Rd
Chillicothe, Ohio 45601
740-779-7500
Adena Regional Medical Center Since 1895, Adena Health System has remained focused on its commitment...
?
mi
from
Chillicothe, OH
Click here to add this to my saved trials
111 S Grant Avenue
Columbus, Ohio 43215
(614) 566-4321
?
mi
from
Columbus, OH
Click here to add this to my saved trials
Columbus, Ohio 43228
?
mi
from
Columbus, OH
Click here to add this to my saved trials
793 West State Street
Columbus, Ohio 43222
614-234-5000
Mount Carmel Health - West Hospital Located near downtown Columbus, Mount Carmel West is the...
?
mi
from
Columbus, OH
Click here to add this to my saved trials
1335 Dublin Road, Suite 124A
Columbus, Ohio 43215
(614) 488-2118
CCOP - Columbus As one of the original 20 CCOPs, the Columbus Community Clinical Oncology...
?
mi
from
Columbus, OH
Click here to add this to my saved trials
18101 Oakwood Blvd
Dearborn, Michigan 48124
(313) 593-8620
Oakwood Cancer Center at Oakwood Hospital and Medical Center In today's health care environment, a...
?
mi
from
Dearborn, MI
Click here to add this to my saved trials
561 W. Central Avenue
Delaware, Ohio 43015
(740) 615-1000
Grady Memorial Hospital As the center of healthcare in Delaware County, Grady Memorial Hospital is...
?
mi
from
Delaware, OH
Click here to add this to my saved trials
Duluth, Minnesota 55805
?
mi
from
Duluth, MN
Click here to add this to my saved trials
400 E Third Street
Duluth, Minnesota 55805
(218) 786-3868
CCOP - Duluth The Duluth CCOP, established and funded by the National Cancer Institute (NCI)...
?
mi
from
Duluth, MN
Click here to add this to my saved trials
502 E 2nd St,
Duluth, Minnesota 55805
(218) 727-8762
Miller - Dwan Medical Center Essentia Health-Duluth, located in the Miller-Dwan building, is a 165-bed...
?
mi
from
Duluth, MN
Click here to add this to my saved trials
41201 Schadden Rd
Elyria, Ohio 44035
(440) 324-0480
Community Cancer Center When you have cancer, you might think first of treatments
?
mi
from
Elyria, OH
Click here to add this to my saved trials
6282 Linton Blvd
Elyria, Ohio 44035
(561) 495-8307
Hematology Oncology Center The Center for Hematology-Oncology was established in 1995 for the purpose of...
?
mi
from
Elyria, OH
Click here to add this to my saved trials
101 S Major St
Eureka, Illinois 61530
(309) 467-2371
Eureka Community Hospital Eureka Community Hospital, established in 1901, offers a wide range of emergency,...
?
mi
from
Eureka, IL
Click here to add this to my saved trials
101 S Major St
Eureka, Illinois 61530
309-467-2371
Illinois CancerCare - Eureka Illinois CancerCare is one of the largest private oncology and hematology...
?
mi
from
Eureka, IL
Click here to add this to my saved trials
801 Broadway N
Fargo, North Dakota 58102
(701) 234-2000
?
mi
from
Fargo, ND
Click here to add this to my saved trials
820 4th Street North
Fargo, North Dakota 58122
(701) 234-6292
CCOP - MeritCare Hospital The Sanford Community Cancer Consortium is a "newly" formed CCOP, merging...
?
mi
from
Fargo, ND
Click here to add this to my saved trials
?
mi
from
Fargo, ND
Click here to add this to my saved trials
302 Kensington Ave
Flint, Michigan 48503
(810) 762-8490
Genesys Hurley Cancer Institute Bringing the most advanced cancer treatment services, technologies and programs available...
?
mi
from
Flint, MI
Click here to add this to my saved trials
Fredericksburg, Virginia 22401
?
mi
from
Fredericksburg, VA
Click here to add this to my saved trials
3315 N. Seminary Street
Galesburg, Illinois 61401
(309) 344-1000
Galesburg Clinic, PC OSF Galesburg Clinic, located on the OSF St. Mary Medical Center campus,...
?
mi
from
Galesburg, IL
Click here to add this to my saved trials
3315 N Seminary St
Galesburg, Illinois 61401
309-344-9269
Illinois CancerCare - Galesburg Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
?
mi
from
Galesburg, IL
Click here to add this to my saved trials
114 Woodland St, Hartford
Hartford, Connecticut 06105
(860) 714-4000
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center While better...
?
mi
from
Hartford, CT
Click here to add this to my saved trials
615 N. Promenade Street
Havana, Illinois 62644
(309) 543-4431
Mason District Hospital Mason District Hospital is dedicated to providing superior healthcare close to home...
?
mi
from
Havana, IL
Click here to add this to my saved trials
520 E. Franklin
Havana, Illinois 62644
309-543-8557
Illinois CancerCare - Havana Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
?
mi
from
Havana, IL
Click here to add this to my saved trials
205 North East Avenue
Jackson, Michigan 49201
?
mi
from
Jackson, MI
Click here to add this to my saved trials
Jacksonville, Florida 32216
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
205 Tenney St
Kewanee, Illinois 61443
309-852-0596
Illinois CancerCare - Kewanee Clinic Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer...
?
mi
from
Kewanee, IL
Click here to add this to my saved trials
401 N Ewing St
Lancaster, Ohio 43130
(740) 687-8000
Fairfield Medical Center We are people you know offering care you trust. Serving more than...
?
mi
from
Lancaster, OH
Click here to add this to my saved trials
1215 E Michigan Ave
Lansing, Michigan 48912
(517) 364-2890
Sparrow Regional Cancer Center Sparrow has grown to become the region's largest health system, and...
?
mi
from
Lansing, MI
Click here to add this to my saved trials
1001 Bellefontaine Ave
Lima, Ohio 45804
(419) 228-3335
Lima Memorial Hospital We also offer an extended network of primary care, pediatric and specialist...
?
mi
from
Lima, OH
Click here to add this to my saved trials
36475 Five Mile
Livonia, Michigan 48154
734-655-4800
St. Mary Mercy Hospital St. Mary Mercy Hospital, located at 36475 Five Mile Road at...
?
mi
from
Livonia, MI
Click here to add this to my saved trials
525 E Grant St
Macomb, Illinois 61455
(309) 833-4101
McDonough District Hospital McDonough District Hospital is centered in Macomb, Illinois, home to Division 1...
?
mi
from
Macomb, IL
Click here to add this to my saved trials
501 E Grant
Macomb, Illinois 61455
309-833-3503
Illinois CancerCare - Macomb Illinois CancerCare is one of the largest private oncology and hematology...
?
mi
from
Macomb, IL
Click here to add this to my saved trials
401 Matthew St
Marietta, Ohio 45750
(740) 376-5000
Strecker Cancer Center at Marietta Memorial Hospital The Memorial Health System's Strecker Cancer Center combines...
?
mi
from
Marietta, OH
Click here to add this to my saved trials
5805 Monclova Rd
Maumee, Ohio 43537
(419) 891-5600
Northwest Ohio Oncology Center The Northwest Ohio Oncology Center, located on the campus of ProMedica...
?
mi
from
Maumee, OH
Click here to add this to my saved trials
500 John Deere Road
Moline, Illinois 61265
(309) 779-5000
Trinity Cancer Center at Trinity Medical Center - 7th Street Campus Located at 500 John...
?
mi
from
Moline, IL
Click here to add this to my saved trials
?
mi
from
Moline, IL
Click here to add this to my saved trials
1000 W Harlem Ave
Monmouth, Illinois 61462
(309) 734-3141
Illinois CancerCare - Monmouth Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
?
mi
from
Monmouth, IL
Click here to add this to my saved trials
1000 W Harlem Ave
Monmouth, Illinois 61462
(309) 734-3141
OSF Holy Family Medical Center OSF Holy Family Medical Center, a part of OSF HealthCare,...
?
mi
from
Monmouth, IL
Click here to add this to my saved trials
Monroe, Michigan 48162
?
mi
from
Monroe, MI
Click here to add this to my saved trials
800 Stewart Rd
Monroe, Michigan 48162
(734) 242-7902
Community Cancer Center of Monroe The Monroe Cancer Center, a joint venture between the Barbara...
?
mi
from
Monroe, MI
Click here to add this to my saved trials
1330 Coshocton Ave
Mount Vernon, Ohio 43050
(740) 393-9000
Knox Community Hospital A community-owned, 115-bed, not-for-profit hospital located in Mount Vernon, Ohio (approximately 40...
?
mi
from
Mount Vernon, OH
Click here to add this to my saved trials
1320 West Main Street
Newark, Ohio 43055
(740) 348-4475
Licking Memorial Cancer Care Program at Licking Memorial Hospital Our Cancer Program has been approved...
?
mi
from
Newark, OH
Click here to add this to my saved trials
Normal, Illinois 61761
?
mi
from
Normal, IL
Click here to add this to my saved trials
407 East Vernon Ave.
Normal, Illinois 61761
(309) 451-8500
Illinois CancerCare - Community Cancer Center At the Community Cancer Center, we are committed to...
?
mi
from
Normal, IL
Click here to add this to my saved trials
1304 Franklin Avenue
Normal, Illinois 61761
309.454.1400
BroMenn Regional Medical Center Advocate BroMenn Medical Center is a general medical and surgical hospital...
?
mi
from
Normal, IL
Click here to add this to my saved trials
407 East Vernon Ave.
Normal, Illinois 61761
(309) 451-8500
Illinois CancerCare - Community Cancer Center At the Community Cancer Center, we are committed to...
?
mi
from
Normal, IL
Click here to add this to my saved trials
2600 Navarre Ave
Oregon, Ohio 43616
(419) 578-7555
?
mi
from
Oregon, OH
Click here to add this to my saved trials
Oregon, Ohio 43616
?
mi
from
Oregon, OH
Click here to add this to my saved trials
?
mi
from
Ottawa, IL
Click here to add this to my saved trials
1100 East Norris Drive
Ottawa, Illinois 61350
(815) 433-3100
Community Hospital of Ottawa Ottawa Regional Hospital, an acute care medical facility, is located on...
?
mi
from
Ottawa, IL
Click here to add this to my saved trials
603 S 13th St
Pekin, Illinois 61554
(309) 353-0214
Illinois CancerCare - Pekin Illinois CancerCare is one of the largest private oncology and hematology...
?
mi
from
Pekin, IL
Click here to add this to my saved trials
603 S 13th St
Pekin, Illinois 61554
(309) 353-0512
Cancer Treatment Center at Pekin Hospital Since 1913, Pekin Hospital has been dedicated to improving...
?
mi
from
Pekin, IL
Click here to add this to my saved trials
530 NE Glen Oak Ave
Peoria, Illinois 61637
(309) 655-2000
OSF St. Francis Medical Center OSF Saint Francis Medical Center, licensed for 616 beds and...
?
mi
from
Peoria, IL
Click here to add this to my saved trials
?
mi
from
Peoria, IL
Click here to add this to my saved trials
?
mi
from
Peoria, IL
Click here to add this to my saved trials
221 NE Glen Oak Ave
Peoria, Illinois 61636
(309) 672-5522
Methodist Medical Center of Illinois UnityPoint Health is one of the nation's most integrated health...
?
mi
from
Peoria, IL
Click here to add this to my saved trials
925 West St
Peru, Illinois 61354
(815) 223-3300
Illinois Valley Community Hospital People
?
mi
from
Peru, IL
Click here to add this to my saved trials
4391 Venture Dr.
Peru, Illinois 61354
815-223-7010
Illinois CancerCare - Peru Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
?
mi
from
Peru, IL
Click here to add this to my saved trials
44405 Woodward Ave
Pontiac, Michigan 48341
(248) 858-3000
St. Joseph Mercy Oakland St. Joseph Mercy Oakland (SJMO) is a 443-bed comprehensive, community and...
?
mi
from
Pontiac, MI
Click here to add this to my saved trials
2601 Electric Ave
Port Huron, Michigan 48060
(810) 985-1500
Mercy Regional Cancer Center at Mercy Hospital The Mercy Regional Cancer Center at St. Joseph...
?
mi
from
Port Huron, MI
Click here to add this to my saved trials
1121 Kinneys Ln
Portsmouth, Ohio 45662
(740) 356-7490
Southern Ohio Medical Center Cancer Center Southern Ohio Medical Center (SOMC) is a 222-bed 501(C)(3)...
?
mi
from
Portsmouth, OH
Click here to add this to my saved trials
530 Park Ave E
Princeton, Illinois 61356
(815) 875-2811
Perry Memorial Hospital Services at Perry include the Perry Memorial Orthopedic and Sports Medicine Clinic;...
?
mi
from
Princeton, IL
Click here to add this to my saved trials
530 Park Ave East
Princeton, Illinois 61356
815-875-3010
Illinois CancerCare - Princeton Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
?
mi
from
Princeton, IL
Click here to add this to my saved trials
353 Fairmont Blvd
Rapid City, South Dakota 57701
(605) 719-1000
Rapid City Regional Hospital Regional Health is an integrated health care system of more than...
?
mi
from
Rapid City, SD
Click here to add this to my saved trials
200 First Street SW
Rochester, Minnesota 55905
507-284-2511
Mayo Clinic Cancer Center The Mayo Clinic Cancer Center is a National Cancer Institute-designated comprehensive...
?
mi
from
Rochester, MN
Click here to add this to my saved trials
800 S Washington Ave
Saginaw, Michigan 48601
(989) 907-8115
Seton Cancer Institute at Saint Mary's - Saginaw At St. Mary's of Michigan, we continue...
?
mi
from
Saginaw, MI
Click here to add this to my saved trials
1200 6th Ave N
Saint Cloud, Minnesota 56303
(320) 252-5131
CentraCare Clinic - River Campus CentraCare Health is a not-for-profit health care system that provides...
?
mi
from
Saint Cloud, MN
Click here to add this to my saved trials
1900 Centracare Cir
Saint Cloud, Minnesota 56303
(320) 229-4907
Coborn Cancer Center CentraCare Health is a not-for-profit health care system that provides comprehensive, high-quality...
?
mi
from
Saint Cloud, MN
Click here to add this to my saved trials
?
mi
from
Sandusky, OH
Click here to add this to my saved trials
5777 E Mayo Blvd
Scottsdale, Arizona 85259
(480) 515-6296
Mayo Clinic Scottsdale Mayo Clinic Arizona was the second Mayo practice to be established outside...
?
mi
from
Scottsdale, AZ
Click here to add this to my saved trials
801 5th St
Sioux City, Iowa 51104
(712) 279-2010
Mercy Medical Center - Sioux City Living the traditions, visions and values of the Sisters...
?
mi
from
Sioux City, IA
Click here to add this to my saved trials
230 Nebraska St.
Sioux City, Iowa 51101
712-252-0088
Siouxland Hematology-Oncology Associates, LLP Siouxland Hematology-Oncology Associates (SHOA) provides medical oncology treatment. In addition to...
?
mi
from
Sioux City, IA
Click here to add this to my saved trials
2720 Stone Park Blvd
Sioux City, Iowa 51104
(712) 279-3500
St. Luke's Regional Medical Center St. Luke's is a patient and family-centered hospital that delivering...
?
mi
from
Sioux City, IA
Click here to add this to my saved trials
600 First Street
Spring Valley, Illinois 61362
815-664-1487
Illinois CancerCare - Spring Valley Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer...
?
mi
from
Spring Valley, IL
Click here to add this to my saved trials
100 Medical Center Drive
Springfield, Ohio 45504
937-523-1000
Community Hospital of Springfield and Clark County For over 100 years, Springfield Regional Medical Center...
?
mi
from
Springfield, OH
Click here to add this to my saved trials
5200 Harroun Rd
Sylvania, Ohio 43560
(419) 824-1444
Flower Hospital Cancer Center Established in 1986, ProMedica is a locally owned, nonprofit healthcare organization...
?
mi
from
Sylvania, OH
Click here to add this to my saved trials
45 St Lawrence Dr
Tiffin, Ohio 44883
(419) 455-7000
Mercy Hospital of Tiffin Mercy Tiffin Hospital was founded in 1913 by the Sisters of...
?
mi
from
Tiffin, OH
Click here to add this to my saved trials