Study of Bone Marrow and Blood Samples From Patients With Leukemia or Other Hematopoietic Cancers



Status:Archived
Conditions:Blood Cancer, Hematology, Leukemia
Therapuetic Areas:Hematology, Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:July 1991

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Cytogenetic Studies in Leukemia Patients


RATIONALE: Studying samples of bone marrow and blood from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer. It may also help doctors predict how patients will respond to
treatment.

PURPOSE: This research study is looking at bone marrow and blood samples from patients with
leukemia or other hematopoietic cancers.


OBJECTIVES:

- Determine the frequency and prognostic significance of cytogenetic abnormalities in
bone marrow or peripheral blood cells in patients with leukemia prior to treatment and
at various times during treatment undergoing treatment on a companion clinical trial.

- Correlate the presence of cytogenetic features with clinical, pathophysiological,
cellular, and molecular characteristics in these patients.

- Determine the frequency of trisomy 12 in patients with chronic lymphocytic leukemia
(CLL) by fluorescence in situ hybridization (FISH) and conventional cytogenetics.

- Determine the feasibility of FISH as a clinical diagnostic technique in patients with
CLL.

- Correlate clinical-pathological prognostic data with the presence of trisomy 12 as
detected by FISH and cytogenetics in patients with CLL.

- Develop a cooperative group mechanism to study chromosome abnormalities by FISH in
patients with leukemia.

- Provide quality control for all Southwest Oncology Group cytogenetic data.

OUTLINE: Bone marrow and/or peripheral blood samples from patients on specific treatment
protocols for leukemia are analyzed for cytogenetic abnormalities. Samples from patients
with chronic lymphocytic leukemia (CLL) are analyzed for trisomy 12 by fluorescence in situ
hybridization and conventional cytogenetics.

PROJECTED ACCRUAL: Approximately 2,500 patients (1,200 with first-line acute myeloid
leukemia [AML], 500 with first-line acute lymphoblastic leukemia [ALL], 200 with relapsed
AML, 125 with chronic phase chronic myelogenous leukemia [CML], 100 with accelerated phase
or blastic phase CML, 250 with hairy cell leukemia, and 125 with relapsed ALL or CLL) will
be accrued for this study within 5 years.


We found this trial at
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211 Saint Francis Drive
Cape Girardeau, Missouri 63703
573-331-3000
Saint Francis Medical Center Saint Francis Medical Center is a 282-bed facility serving more than...
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1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
(505) 272-4946
University of New Mexico Cancer Center It’s been 40 years since the New Mexico State...
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100 E. Idaho St.
Boise City, Idaho 83712
208-381-2711
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2720 Clare Avenue
Bremerton, Washington 98310
360-479-6154
Olympic Hematology and Oncology We provide outpatient cancer services in a refined environment designed specifically...
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200 Hawthorne Lane
Charlotte, North Carolina 28233
704-384-4000
Presbyterian Cancer Center at Presbyterian Hospital At Novant Health Presbyterian Medical Center, we are welcoming...
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
University of Chicago One of the world's premier academic and research institutions, the University of...
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1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
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9040 Fitzsimmons
Fort Lewis-DuPont, Washington 98431
253-968-2505
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2700 Wayne Memorial Drive
Goldsboro, North Carolina 27534
(919) 736-1110
Wayne Memorial Hospital, Incorporated Wayne Memorial Hospital, an affiliate of Wayne Health Corporation, is home...
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200 North Park Street
Kalamazoo, Michigan 49007
(269) 382-2500
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
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524 South Park Street
Kalamazoo, Michigan 49007
(269) 341-7654
Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
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701 Doctors Dr
Kinston, North Carolina 28504
(252) 559-2200
Kinston Medical Specialists offers comprehensive medical services for all ages. Whether it’s a case of...
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1800 West Charleston Boulevard
Las Vegas, Nevada 89102
(702) 383-2000
University Medical Center of Southern Nevada University Medical Center is dedicated to providing the highest...
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800 Rose St
Lexington, Kentucky 40536
(859) 257-4488
Lucille P. Markey Cancer Center at University of Kentucky The Markey Cancer Center was founded...
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1415 E. Kincaid
Mount Vernon, Washington 98273
360-424-4111
Skagit Valley Hospital Cancer Care Center We know that treatment takes its toll physically, emotionally...
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1400 South Orange Avenue
Orlando, Florida 32806
407-648-3800
M. D. Anderson Cancer Center Welcome to UF Health Cancer Center at Orlando Health. For...
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3181 SW Sam Jackson Park Rd
Portland, Oregon 97239
(503) 494-5058
Knight Cancer Institute at Oregon Health and Science University Cancer takes many forms. Although cancer...
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19500 10th Ave NE # 100
Poulsbo, Washington 98370
(360) 598-7500
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2279 45th Street
Sacramento, California 95817
(916) 734-5800
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4502 Medical Drive
San Antonio, Texas 78284
(210) 567-7000
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1100 Fairview Avenue North
Seattle, Washington 98109
(206) 667-5000
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201 16th Avenue East
Seattle, Washington 98112
(206) 326-3000
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1959 NE Pacific St
Seattle, Washington 98195
(206) 598-4100
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601 South Sherman Street
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(509) 228-1000
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1717 S J St
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(253) 426-4101
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820 North Chelan Avenue
Wenatchee, Washington 98801
509) 663-8711
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1 Akron General Ave
Akron, Ohio 44307
(330) 344-6000
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Albany, Georgia 31701
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1415 Tulane Ave., HC-62
Alexandria, Louisiana 70112
504-988-6121
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Anderson, South Carolina 29621
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Ann Arbor, Michigan 48706
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Ann Arbor, Michigan 48103
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5301 East Huron River Drive
Ann Arbor, Michigan 48106
1.877.590.5995
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1500 East Medical Center Drive
Ann Arbor, Michigan 48109
800-865-1125
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Ann Arbor, Michigan 48106
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Atlanta, Georgia 30342
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5665 Peachtree Dunwoody Rd NE
Atlanta, Georgia 30342
(678) 843-7001
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1968 Peachtree Rd NW
Atlanta, Georgia 30309
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1000 Johnson Ferry Rd NE
Atlanta, Georgia 30342
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2000 Ogden Avenue
Aurora, Illinois 60504
630-978-6200
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Austell, Georgia 30106
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Baltimore, Maryland 21215
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300 North Ave
Battle Creek, Michigan 49017
(269) 245-8000
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205 Palmer Ave.
Bellefontaine, Ohio 43311
937.592.4015
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Berkeley, California 94704
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801 Ostrum St
Bethlehem, Pennsylvania 18015
(484) 526-4000
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1351 Kimberly Rd
Bettendorf, Iowa 52722
(563) 355-7733
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605 Oak St
Big Rapids, Michigan 49307
(231) 796-8691
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90 Poly Drive, Suite 2
Billings, Montana 59101
(406) 237-5460
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Billings, Montana 59101
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801 N. 29th St
Billings, Montana 59107
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1101 N 27th St # 201
Billings, Montana 59101
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931 Highland Blvd
Bozeman, Montana 59715
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506 6th St
Brooklyn, New York 11215
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501 S Buena Vista St
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Burlingame, California 94010
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Canton, Ohio 44710
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6501 E 2nd St
Casper, Wyoming 82609
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1303 North Main Street
Cedar City, Utah 84721
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914 S Scheuber Rd
Centralia, Washington 98531
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505 S Plummer Ave
Chanute, Kansas 66720
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171 Ashley Avenue
Charleston, South Carolina 29425
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Chattanooga, Tennessee 37404
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272 Hospital Rd
Chillicothe, Ohio 45601
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12961 27th Ave
Chippewa Falls, Wisconsin 54729
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Cincinnati, Ohio 45267
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9280 SE Sunnybrook Blvd #100
Clackamas, Oregon 97015
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1831 Fifth Avenue
Columbus, Georgia 31904
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Columbus, Ohio 43228
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111 S Grant Avenue
Columbus, Ohio 43215
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793 West State Street
Columbus, Ohio 43222
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Danville, Virginia 24541
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Dayton, Ohio 45409
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405 W Grand Ave
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2222 Philadelphia Dr
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9000 North Main Street
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3123 Research Boulevard Suite 150
Dayton, Ohio 45420
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18101 Oakwood Blvd
Dearborn, Michigan 48124
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2300 N. Edward Street
Decatur, Illinois 62526
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561 W. Central Avenue
Delaware, Ohio 43015
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Des Moines, Iowa 50309
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1221 Pleasant St Suite 100
Des Moines, Iowa 50309
(515) 282-2921
Medical Oncology and Hematology Associates at John Stoddard Cancer Center Iowa's first children's cancer center...
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1221 Pleasant St Suite 100
Des Moines, Iowa 50309
(515) 282-2921
Medical Oncology and Hematology Associates at John Stoddard Cancer Center Iowa's first children's cancer center...
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1221 Pleasant St
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(515) 241-4141
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411 Laurel St New Visions
Des Moines, Iowa 50314
(515) 247-3970
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411 Laurel Street
Des Moines, Iowa 50314
(515) 247-3121
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4201 St Antoine St
Detroit, Michigan 48201
(313) 577-1429
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2799 W Grand Blvd
Detroit, Michigan 48202
(888) 777-4167
Josephine Ford Cancer Center at Henry Ford Hospital A diagnosis of cancer is one of...
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2020 Central Ave
Dodge City, Kansas 67801
(620) 227-2488
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