Collecting, Analyzing, and Storing Tissue Samples From Patients With Non-Hodgkin's Lymphoma



Status:Archived
Conditions:Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:February 1989

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Central Lymphoma Repository Tissue Procurement Protocol


RATIONALE: Collecting and storing samples of tissue from patients with cancer to study in
the laboratory may help doctors learn more about changes that may occur in DNA and identify
biomarkers related to cancer. It may also help doctors learn how patients respond to
treatment.

PURPOSE: This laboratory study is collecting, analyzing, and storing tissue samples from
patients with non-Hodgkin's lymphoma.


OBJECTIVES:

- Establish a central lymphoma tissue repository of fresh snap-frozen tissue from
patients with previously untreated non-Hodgkin's lymphoma (NHL).

- Determine a standard set of procedures for routine acquisition, banking, and study of
these tissue samples.

- Correlate presently activated phenotyping studies and future projected molecular
studies of the DNA and RNA status of these tissue samples with clinical results.

- Correlate pretreatment phenotype or genotype of tissue samples from patients with
intermediate- or high-grade NHL with patient outcome, in terms of complete response
rate, time to progression, and survival.

- Correlate the lymphoma lineage (T-cell vs B-cell), loss of class II human
histocompatibility antigen status (HLA-DR-positive vs HLA-DR-negative), proliferative
index (as measured by Ki-67), and B- or T-cell antigen aberrancy (e.g., lack of Pan B
or T antigen expression) with outcome in patients with intermediate- or high-grade NHL.

OUTLINE: Patients are treated on the SWOG study on which they are enrolled.

Tissue samples obtained before treatment began are banked in a tissue repository.

Samples from patients with intermediate- or high-grade non-Hodgkin's lymphoma are analyzed
by three-stage immunohistochemistry using monoclonal antibodies to B-cell antigens, T-cell
antigens, immunoglobulins, CALLA, HLA-DR, anti-interleukin-2 receptor, and Ki-67 (for the
proliferative index). Phenotype (immune marker status, proliferation status, and activation
status) is correlated with response to treatment, relapse, and overall survival.

PROJECTED ACCRUAL: Approximately 495 patients will be accrued for this study.


We found this trial at
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1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
(505) 272-4946
University of New Mexico Cancer Center It’s been 40 years since the New Mexico State...
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100 E. Idaho St.
Boise City, Idaho 83712
208-381-2711
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2720 Clare Avenue
Bremerton, Washington 98310
360-479-6154
Olympic Hematology and Oncology We provide outpatient cancer services in a refined environment designed specifically...
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1000 Blythe Blvd
Charlotte, North Carolina 28203
(704) 355-2000
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200 Hawthorne Lane
Charlotte, North Carolina 28233
704-384-4000
Presbyterian Cancer Center at Presbyterian Hospital At Novant Health Presbyterian Medical Center, we are welcoming...
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1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
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2700 Wayne Memorial Drive
Goldsboro, North Carolina 27534
(919) 736-1110
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401 W Greenlawn Ave
Lansing, Michigan 48910
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800 Rose St
Lexington, Kentucky 40536
(859) 257-4488
Lucille P. Markey Cancer Center at University of Kentucky The Markey Cancer Center was founded...
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1415 E. Kincaid
Mount Vernon, Washington 98273
360-424-4111
Skagit Valley Hospital Cancer Care Center We know that treatment takes its toll physically, emotionally...
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3181 SW Sam Jackson Park Rd
Portland, Oregon 97239
(503) 494-5058
Knight Cancer Institute at Oregon Health and Science University Cancer takes many forms. Although cancer...
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19500 10th Ave NE # 100
Poulsbo, Washington 98370
(360) 598-7500
Harrison Poulsbo Hematology and Onocology Harrison Poulsbo's new Hematology & Oncology center provides outpatient cancer...
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4502 Medical Drive
San Antonio, Texas 78284
(210) 567-7000
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1100 Fairview Avenue North
Seattle, Washington 98109
(206) 667-5000
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1959 NE Pacific St
Seattle, Washington 98195
(206) 598-4100
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201 16th Avenue East
Seattle, Washington 98112
(206) 326-3000
Group Health Central Hospital Group Health Cooperative is a member-governed, nonprofit health care system that...
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601 South Sherman Street
Spokane, Washington 99202
(509) 228-1000
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1717 S J St
Tacoma, Washington 98405
(253) 426-4101
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12902 USF Magnolia Dr
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(888) 663-3488
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820 North Chelan Avenue
Wenatchee, Washington 98801
509) 663-8711
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Anchorage, Alaska 99508
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Anderson, South Carolina 29621
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Ann Arbor, Michigan 48706
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Ann Arbor, Michigan 48106
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5301 East Huron River Drive
Ann Arbor, Michigan 48106
1.877.590.5995
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Atlanta, Georgia 30342
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5665 Peachtree Dunwoody Rd NE
Atlanta, Georgia 30342
(678) 843-7001
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1968 Peachtree Rd NW
Atlanta, Georgia 30309
(404) 605-5000
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1000 Johnson Ferry Rd NE
Atlanta, Georgia 30342
(404) 851-8000
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Austell, Georgia 30106
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205 Palmer Ave.
Bellefontaine, Ohio 43311
937.592.4015
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Berkeley, California 94704
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801 Ostrum St
Bethlehem, Pennsylvania 18015
(484) 526-4000
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801 N. 29th St
Billings, Montana 59107
406.238.2500
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1101 N 27th St # 201
Billings, Montana 59101
(406) 237-3585
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Billings, Montana 59101
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90 Poly Drive, Suite 2
Billings, Montana 59101
(406) 237-5460
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931 Highland Blvd
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(406) 585-5070
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6501 E 2nd St
Casper, Wyoming 82609
(307) 235-5433
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914 S Scheuber Rd
Centralia, Washington 98531
(360) 736-2803
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505 S Plummer Ave
Chanute, Kansas 66720
(620) 431-7580
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272 Hospital Rd
Chillicothe, Ohio 45601
740-779-7500
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9280 SE Sunnybrook Blvd #100
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(503) 513-3300
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1831 Fifth Avenue
Columbus, Georgia 31904
(706) 320-8700
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111 S Grant Avenue
Columbus, Ohio 43215
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5100 W Broad St
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(614) 544-1000
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793 West State Street
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142 S Main St
Danville, Virginia 24541
(434) 799-2100
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Davenport, Iowa 52803
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1 Wyoming St
Dayton, Ohio 45409
(937) 208-2300
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9000 North Main Street
Dayton, Ohio 45415
(937) 734-5800
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405 W Grand Ave
Dayton, Ohio 45405
(937) 723-3200
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2222 Philadelphia Dr
Dayton, Ohio 45406
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3123 Research Boulevard Suite 150
Dayton, Ohio 45420
(937) 775-1350
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18101 Oakwood Blvd
Dearborn, Michigan 48124
(313) 593-8620
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561 W. Central Avenue
Delaware, Ohio 43015
(740) 615-1000
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Denville, New Jersey 07834
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4201 St Antoine St
Detroit, Michigan 48201
(313) 577-1429
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2020 Central Ave
Dodge City, Kansas 67801
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700 West Central
El Dorado, Kansas 67042
(316) 889-0099
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Fairfield, California 94533
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34515 Ninth Ave. S.
Federal Way, Washington 98003
(253) 944-8100
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200 West Pearl Street
Findlay, Ohio 45840
419-424-0380
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555 East Cheves Street
Florence, South Carolina 29506
843-777-2000
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Fort Scott, Kansas 66701
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105 Mcknight Drive
Franklin, Ohio 45005
513-424-2111
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1117 29th St S Ste 500
Great Falls, Montana 59405
(406) 731-8100
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Great Falls, Montana 59405
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1101 26th Street South
Great Falls, Montana 59405
406.455.5000
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835 Sweitzer St
Greenville, Ohio 45331
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114 Woodland St, Hartford
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30 13th St
Havre, Montana 59501
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2475 Broadway St
Helena, Montana 59601
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800 N Justice St
Hendersonville, North Carolina 28791
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800 W. Laurel
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205 Northeast Ave
Jackson, Michigan 49201
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Jackson, Mississippi 39216
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75 Claremont St Ste E
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(406) 752-7600
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310 Sunnyview Ln
Kalispell, Montana 59901
(406) 752-5111
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Kansas City, Missouri 64114
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2800 Clay Edwards Dr
Kansas City, Missouri 64116
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2316 E Meyer Blvd
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(816) 276-4000
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Kansas City, Missouri 64116
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2301 Holmes
Kansas City, Missouri 64108
816-404-1000
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Kearney, Nebraska 68848
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7360 W. Deschutes
Kennewick, Washington 99336
509-783-0144
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750 Avenue D West
Kingman, Kansas 67068
(620) 532-3147
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1915 White Ave.
Knoxville, Tennessee 37916
(865) 541-1678
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401 N Ewing St
Lancaster, Ohio 43130
(740) 687-8000
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1215 E Michigan Ave
Lansing, Michigan 48912
(517) 364-2890
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325 Maine Street
Lawrence, Kansas 66044
(785) 505-5000
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Lawrenceville, Georgia 30045
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Leavenworth, Kansas 66048
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100 NE St Lukes Blvd
Lee's Summit, Missouri 64086
(816) 347-5000
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